Deposition of type X collagen in the cartilage extracellular matrix

R. Cancedda, O. Capasso, P. Castagnola, F. Descalzi-Cancedda, N. Quarto

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In cultured chick embryo chondrocytes, type X collagen is preferentially deposited in the extracellular matrix, the ratio between type II and type X collagen being about 5 times higher in the culture medium than in the cell layer. When the newly synthesized collagens deposited in slices from the epiphyseal cartilage of 17-day-old embryo tibiae were isolated, type X collagen was always the major species. In agreement with this result the mRNA for type X collagen was the predominant mRNA species purified from the same tissue. When the total collagen (unlabeled) deposited in the epiphyseal cartilage was analyzed, it was observed that type X collagen represented only 1/15 of the type II collagen recovered in the same preparation. The possible explanations for these differences are discussed.

Original languageEnglish
Pages (from-to)7-14
Number of pages8
JournalJournal of Cellular Biochemistry
Volume28
Issue number1
DOIs
Publication statusPublished - 1985

Fingerprint

Collagen Type X
Cartilage
Extracellular Matrix
Growth Plate
Collagen Type II
Collagen
Messenger RNA
Chick Embryo
Chondrocytes
Tibia
Culture Media
Embryonic Structures
Cells
Tissue

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

Deposition of type X collagen in the cartilage extracellular matrix. / Cancedda, R.; Capasso, O.; Castagnola, P.; Descalzi-Cancedda, F.; Quarto, N.

In: Journal of Cellular Biochemistry, Vol. 28, No. 1, 1985, p. 7-14.

Research output: Contribution to journalArticle

Cancedda, R. ; Capasso, O. ; Castagnola, P. ; Descalzi-Cancedda, F. ; Quarto, N. / Deposition of type X collagen in the cartilage extracellular matrix. In: Journal of Cellular Biochemistry. 1985 ; Vol. 28, No. 1. pp. 7-14.
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