Depressed fibrinolysis in patients with acute leukaemia

A. Guarini, L. Mussoni, L. Gugliotta, L. Chetti, T. Niewiarowski, L. Catani, S. Macchi, M. B. Donati, S. Tura

Research output: Contribution to journalArticlepeer-review

Abstract

The fibrinolytic system was studied in 46 patients with acute leukaemia at diagnosis. Untreated patients (with the sole exception of the M3 subgroup) showed an inhibition of fibrinolytic activity, measured by the euglobulin lysis time and area. This inhibition was accompanied by reduced t-PA antigen and t-PA inhibitor activity. No correlation was found between the above-mentioned fibrinolytic parameters and the biochemical haematological values considered, nor with clinical and/or laboratory features of DIC, fever, liver failure. The decrease in immunological plasminogen and functional α2-antiplasmin, showed a significant correlation with the presence of clinical and/or laboratory signs of DIC, as diagnosed on the basis of concomitant increase in fibrin monomers, plasmatic fibrinopeptide A and serum FDP.

Original languageEnglish
Pages (from-to)327-330
Number of pages4
JournalBritish Journal of Haematology
Volume66
Issue number3
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Hematology

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