OBNIZONA ZMIENNOSC RYTMU SERCA JEST NIEZALEZNYM CZYNNIKIEM RYZYKA ZGONU U CHORYCH Z ZAAWANSOWANA NIEWYDOLNOSCIA KRAZENIA

Translated title of the contribution: Depressed heart rate variability as an independent predictor of mortality in patients with advanced chronic heart failure

P. Ponikowski, S. D. Anker, R. Szelemej, W. Banasiak, D. Kratochwil, B. Sobkowicz, A. J S Coats, K. Wrabec

Research output: Contribution to journalArticlepeer-review

Abstract

The prognostic value of the analysis of heart rate variability (HRV) in patients with chronic heart failure (CHF) remains controversial. The aim of the study was to evaluate whether depressed HRV was associated with a higher risk of death during 12-month follow-up in patients with advanced CHF. Seventy four patients with moderate to severe CHF (mean age: 58 years, NYHA class II-IV, left ventricular ejection fraction (LVEF): 24%, peak oxygen consumption (VO(2max)): 16.7 ml/kg/min) due to idiopathic dilated cardiomyopathy (20 pts) and ischaemic heart disease (54 pts) were included into the study. In the prognostic analysis using Cox proportional hazard model and Kaplan-Meier survival analysis, the following factors were investigated: age, CHF etiology, NYHA class, LVEF, VO(2max), presence of ventricular tachycardia episodes on Holter monitoring and HRV measures derived from 24 hour ECG monitoring, calculated in the time-domain (SDNN, SDANN, pNN50) and frequency-domain (LF, HF). During 1 year follow-up 9 patients (12%) died (mean time to death: 114 ± 115 days, 3-311 days). In the univariate analysis the following factors were found to be independent, significant predictors of death: LVEF (chi2=4.01, p=0.045). VO(2max) 2=4.52, p=0.034), SDNN (chi2=7.13, p=0.008), SDANN (chi2=6.97, p=0.008) and InLF (chi2=10.27, p=0.001). The multivariate analysis revealed that the HRV parameters (SDNN, SDANN, InLF) were predictors of survival independently of LVEF i VO(2max). In the Kaplan-Meier analysis SDNN 100 ms (p=0.039). Moreover, the presence of 2 risk factors VO(2max)

Translated title of the contributionDepressed heart rate variability as an independent predictor of mortality in patients with advanced chronic heart failure
Original languagePolish
Pages (from-to)514-521
Number of pages8
JournalKardiologia polska.
Volume45
Issue number12
Publication statusPublished - 1996

Keywords

  • Chronic heart failure
  • Heart rate variability
  • Mortality

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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