Depressed urinary excretion of epidermal growth factor in psoriasis

Paolo Madeddu, Pasquale Ena, Paolo Pinna Parpaglia, Giovanna Patteri, Sofia Bacciu, Mario Maioli, Nicola Glorioso

Research output: Contribution to journalArticlepeer-review

Abstract

Epidermal growth factor (EOF) may have a modulatory role in renal growth and function. The aim of the present study was to evaluate whether urinary excretion of EGF is altered in psoriatic patients with or without arterial hypertension. The glomerular filtration rate was similar in psoriatics as compared with age- and sex-matched controls, whereas urinary EGF (μg/g creatinine) was significantly reduced in psoriatics: normotensive subjects. 29.52 ± 3.51 (psoriatics) versus 44.31 ± 1.20 (controls, p <0.05); hypertensive subjects. 19.67 ± 3.96 (psoriatics) versus 30.11 ± 1.52 (controls, p <0.05). The urinary EGF excretion was lower in males than in females, save for hypertensive psoriatics. Urinary EGF correlated inversely with age and directly with urinary kallikrein excretion. Urinary kallikrein activity was reduced and microalbuminuria increased in hypertensive psoriatics. These alterations might suggest that initial deterioration of renal function is present in psoriasis.

Original languageEnglish
Pages (from-to)313-317
Number of pages5
JournalAmerican Journal of Nephrology
Volume11
Issue number4
DOIs
Publication statusPublished - 1991

Keywords

  • Growth factors
  • High blood pressure
  • Psoriasis
  • Renal function

ASJC Scopus subject areas

  • Nephrology

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