Depression after first-ever ischemic stroke: The prognostic role of neuroanatomic subtypes in clinical practice

Leandro Provinciali, Stefano Paolucci, Riccardo Torta, Vito Toso, Beatrice Gobbi, Carlo Gandolfo

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The relationship between poststroke depression (PSD) and Oxford Community Stroke Project (OCSP) subtypes is uncertain. Methods: 713 first-ever ischemic stroke patients recruited in a multicenter investigation to evaluate prevalence, onset time and severity of PSD. Stroke subtypes were considered as independent predictors of PSD occurrence by logistic regression. Results: Results showed similar prevalence of PSD in stroke subtypes with the exception of TACI. Only patients with total anterior cerebral ischemia (TACI) showed a higher PSD occurrence (OR: 1.76, CI: 1.14-2.71). Multivariate analysis underlined the role of severe functional impairment, previous depressive disorders and female sex. Neither the OCSP subgroups, nor left and right involvement were predictive of PSD. TACI and left-sided strokes were related to higher depression severity scores. Conclusions: In clinical practice, the definition of neuroanatomic subtypes provides little contribution specifically to PSD prediction after a first-ever ischemic stroke.

Original languageEnglish
Pages (from-to)592-599
Number of pages8
JournalCerebrovascular Diseases
Volume26
Issue number6
DOIs
Publication statusPublished - Dec 2008

Keywords

  • Depression after stroke
  • Ischemic stroke
  • Neuroanatomy
  • Poststroke depression
  • Prognosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Cardiology and Cardiovascular Medicine

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