Abstract
Background: Mixed evidence in the general population and medically ill patients has suggested that homozygous carriers of the short allele (s/s) of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) may increase the risk of depression in comparison with carriers of the long allele (l/l) or s/l. Given the lack of data in oncology, we examined the relationship of depression with the 5-HTTLPR and psychosocial variables among breast cancer patients. Methods: A sample of 145 breast cancer patients were studied as regards to depression, psychosocial-related variables (coping, Type D-personality, life events, and social support), and the 5-HTTLPR, which was genotyped by using a standard protocol with DNA extracted from the blood. Results: No difference was found between s/s, s/l and l/l patients on depression and any other psychosocial variable. No gene-by environment (G × E) interactions were observed between the 5-HTTLPR and recent life events. Conclusions: The study did not provide support of a possible association between 5-HTTLPR polymorphism, alone or in conjunction with life events, and depression in newly diagnosed breast cancer. Further follow-up studies are however necessary to confirm these data.
| Original language | English |
|---|---|
| Pages (from-to) | 346-350 |
| Number of pages | 5 |
| Journal | Journal of Affective Disorders |
| Volume | 124 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Aug 2010 |
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Keywords
- 5-HTTLPR polymorphism
- Cancer
- Depression
ASJC Scopus subject areas
- Psychiatry and Mental health
- Clinical Psychology
Cite this
Depression and serotonin transporter (5-HTTLPR) polymorphism in breast cancer patients. / Grassi, Luigi; Rossi, Elena; Cobianchi, Marina; Aguiari, Letizia; Capozzo, Marianna; Martinis, Elisabetta; Nanni, Maria Giulia; Lelli, Giorgio; Schillani, Giulia; Biancosino, Bruno; Giraldi, Tullio.
In: Journal of Affective Disorders, Vol. 124, No. 3, 08.2010, p. 346-350.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Depression and serotonin transporter (5-HTTLPR) polymorphism in breast cancer patients
AU - Grassi, Luigi
AU - Rossi, Elena
AU - Cobianchi, Marina
AU - Aguiari, Letizia
AU - Capozzo, Marianna
AU - Martinis, Elisabetta
AU - Nanni, Maria Giulia
AU - Lelli, Giorgio
AU - Schillani, Giulia
AU - Biancosino, Bruno
AU - Giraldi, Tullio
PY - 2010/8
Y1 - 2010/8
N2 - Background: Mixed evidence in the general population and medically ill patients has suggested that homozygous carriers of the short allele (s/s) of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) may increase the risk of depression in comparison with carriers of the long allele (l/l) or s/l. Given the lack of data in oncology, we examined the relationship of depression with the 5-HTTLPR and psychosocial variables among breast cancer patients. Methods: A sample of 145 breast cancer patients were studied as regards to depression, psychosocial-related variables (coping, Type D-personality, life events, and social support), and the 5-HTTLPR, which was genotyped by using a standard protocol with DNA extracted from the blood. Results: No difference was found between s/s, s/l and l/l patients on depression and any other psychosocial variable. No gene-by environment (G × E) interactions were observed between the 5-HTTLPR and recent life events. Conclusions: The study did not provide support of a possible association between 5-HTTLPR polymorphism, alone or in conjunction with life events, and depression in newly diagnosed breast cancer. Further follow-up studies are however necessary to confirm these data.
AB - Background: Mixed evidence in the general population and medically ill patients has suggested that homozygous carriers of the short allele (s/s) of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) may increase the risk of depression in comparison with carriers of the long allele (l/l) or s/l. Given the lack of data in oncology, we examined the relationship of depression with the 5-HTTLPR and psychosocial variables among breast cancer patients. Methods: A sample of 145 breast cancer patients were studied as regards to depression, psychosocial-related variables (coping, Type D-personality, life events, and social support), and the 5-HTTLPR, which was genotyped by using a standard protocol with DNA extracted from the blood. Results: No difference was found between s/s, s/l and l/l patients on depression and any other psychosocial variable. No gene-by environment (G × E) interactions were observed between the 5-HTTLPR and recent life events. Conclusions: The study did not provide support of a possible association between 5-HTTLPR polymorphism, alone or in conjunction with life events, and depression in newly diagnosed breast cancer. Further follow-up studies are however necessary to confirm these data.
KW - 5-HTTLPR polymorphism
KW - Cancer
KW - Depression
UR - http://www.scopus.com/inward/record.url?scp=77953806773&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77953806773&partnerID=8YFLogxK
U2 - 10.1016/j.jad.2009.12.022
DO - 10.1016/j.jad.2009.12.022
M3 - Article
C2 - 20122741
AN - SCOPUS:77953806773
VL - 124
SP - 346
EP - 350
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
IS - 3
ER -