Depression and serotonin transporter (5-HTTLPR) polymorphism in breast cancer patients

Luigi Grassi, Elena Rossi, Marina Cobianchi, Letizia Aguiari, Marianna Capozzo, Elisabetta Martinis, Maria Giulia Nanni, Giorgio Lelli, Giulia Schillani, Bruno Biancosino, Tullio Giraldi

Research output: Contribution to journalArticle

Abstract

Background: Mixed evidence in the general population and medically ill patients has suggested that homozygous carriers of the short allele (s/s) of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) may increase the risk of depression in comparison with carriers of the long allele (l/l) or s/l. Given the lack of data in oncology, we examined the relationship of depression with the 5-HTTLPR and psychosocial variables among breast cancer patients. Methods: A sample of 145 breast cancer patients were studied as regards to depression, psychosocial-related variables (coping, Type D-personality, life events, and social support), and the 5-HTTLPR, which was genotyped by using a standard protocol with DNA extracted from the blood. Results: No difference was found between s/s, s/l and l/l patients on depression and any other psychosocial variable. No gene-by environment (G × E) interactions were observed between the 5-HTTLPR and recent life events. Conclusions: The study did not provide support of a possible association between 5-HTTLPR polymorphism, alone or in conjunction with life events, and depression in newly diagnosed breast cancer. Further follow-up studies are however necessary to confirm these data.

Original languageEnglish
Pages (from-to)346-350
Number of pages5
JournalJournal of Affective Disorders
Volume124
Issue number3
DOIs
Publication statusPublished - Aug 2010

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Serotonin Plasma Membrane Transport Proteins
Depression
Breast Neoplasms
Type D Personality
Alleles
Gene-Environment Interaction
Social Support
DNA
Population
Genes

Keywords

  • 5-HTTLPR polymorphism
  • Cancer
  • Depression

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Grassi, L., Rossi, E., Cobianchi, M., Aguiari, L., Capozzo, M., Martinis, E., ... Giraldi, T. (2010). Depression and serotonin transporter (5-HTTLPR) polymorphism in breast cancer patients. Journal of Affective Disorders, 124(3), 346-350. https://doi.org/10.1016/j.jad.2009.12.022

Depression and serotonin transporter (5-HTTLPR) polymorphism in breast cancer patients. / Grassi, Luigi; Rossi, Elena; Cobianchi, Marina; Aguiari, Letizia; Capozzo, Marianna; Martinis, Elisabetta; Nanni, Maria Giulia; Lelli, Giorgio; Schillani, Giulia; Biancosino, Bruno; Giraldi, Tullio.

In: Journal of Affective Disorders, Vol. 124, No. 3, 08.2010, p. 346-350.

Research output: Contribution to journalArticle

Grassi, L, Rossi, E, Cobianchi, M, Aguiari, L, Capozzo, M, Martinis, E, Nanni, MG, Lelli, G, Schillani, G, Biancosino, B & Giraldi, T 2010, 'Depression and serotonin transporter (5-HTTLPR) polymorphism in breast cancer patients', Journal of Affective Disorders, vol. 124, no. 3, pp. 346-350. https://doi.org/10.1016/j.jad.2009.12.022
Grassi, Luigi ; Rossi, Elena ; Cobianchi, Marina ; Aguiari, Letizia ; Capozzo, Marianna ; Martinis, Elisabetta ; Nanni, Maria Giulia ; Lelli, Giorgio ; Schillani, Giulia ; Biancosino, Bruno ; Giraldi, Tullio. / Depression and serotonin transporter (5-HTTLPR) polymorphism in breast cancer patients. In: Journal of Affective Disorders. 2010 ; Vol. 124, No. 3. pp. 346-350.
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