Depression, apathy and impaired self-awareness following severe traumatic brain injury: a preliminary investigation

U. Bivona, A. Costa, M. Contrada, D. Silvestro, E. Azicnuda, M. Aloisi, G. Catania, P. Ciurli, C. Guariglia, C. Caltagirone, R. Formisano, G. P. Prigatano

Research output: Contribution to journalArticle

Abstract

Primary Objective: The primary aim of this study was to determine the frequency of severe impaired self-awareness (ISA) in patients with severe traumatic brain injury (TBI) and the correlates of selected clinical, neuropsychiatric and cognitive variables. The secondary aim of the study was to assess depression and apathy on the basis of their level of self-awareness. Methods: Thirty patients with severe TBI and 30 demographically matched healthy control subjects (HCs) were compared on measures of ISA, depression, anxiety, alexithymia, neuropsychiatric symptoms and cognitive flexibility. Results: Twenty percent of the patients demonstrated severe ISA. Severe post-acute ISA was associated with more severe cognitive inflexibility, despite the absence of differences in TBI severity, as evidenced by a Glasgow Coma Scale (GCS) score lower than 9 in all cases in the acute phase. Patients with severe ISA showed lower levels of depression and anxiety but tended to show more apathy and to have greater difficulty describing their emotional state than patients with severe TBI who showed minimal or no disturbance in self-awareness. Conclusion: These findings support the general hypothesis that severe ISA following severe TBI is typically not associated with depression and anxiety, but rather with apathy and cognitive inflexibility.

Original languageEnglish
Pages (from-to)1245-1256
Number of pages12
JournalBrain Injury
Volume33
Issue number9
DOIs
Publication statusPublished - Jul 29 2019

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Apathy
Depression
Anxiety
Neurobehavioral Manifestations
Glasgow Coma Scale
Affective Symptoms
Healthy Volunteers
Traumatic Brain Injury

Keywords

  • apathy
  • mood disorders
  • neuropsychological rehabilitation
  • self-awareness
  • Severe traumatic brain injury

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Developmental and Educational Psychology
  • Clinical Neurology

Cite this

Depression, apathy and impaired self-awareness following severe traumatic brain injury : a preliminary investigation. / Bivona, U.; Costa, A.; Contrada, M.; Silvestro, D.; Azicnuda, E.; Aloisi, M.; Catania, G.; Ciurli, P.; Guariglia, C.; Caltagirone, C.; Formisano, R.; Prigatano, G. P.

In: Brain Injury, Vol. 33, No. 9, 29.07.2019, p. 1245-1256.

Research output: Contribution to journalArticle

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