Depression of biliary glutathione excretion by chronic ethanol feeding in the rat

Gianluigi Vendemiale, Elizabeth Jayatilleke, Spencer Shaw, Charles S. Lieber

Research output: Contribution to journalArticle

Abstract

The effects of chronic alcohol feeding on biliary glutathione excretion were studied in rats pair fed diets containing either ethanol (36% of total energy) or isocaloric carbodydrate for 4-6 weeks. An exteriorized biliary-duodenal fistula was established and total glutathione (GSH) and oxidized glutathione (GSSG) were measured. A significant decrease was observed in rats fed alcohol chronically compared to their pair fed controls in the biliary excretion of GSH (55.7±37.0 vs 243.1±29.0 μg/ml bile, p35-L-methionine incorporation into hepatic and biliary GSH was unchanged or even increased after chronic ethanol feeding.

Original languageEnglish
Pages (from-to)1065-1073
Number of pages9
JournalLife Sciences
Volume34
Issue number11
DOIs
Publication statusPublished - Mar 12 1984

ASJC Scopus subject areas

  • Pharmacology

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