Depression—A Major Contributor to Poor Quality of Life in Patients With Advanced Cancer

Kjersti S. Grotmol, Hanne C. Lie, Marianne J. Hjermstad, Nina Aass, David Currow, Stein Kaasa, Torbjørn Moum, Alessandra Pigni, Jon Håvard Loge, European Palliative Care Research Collaborative (EPCRC)

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Context Quality of life (QoL) and depression are important patient-reported outcomes in cancer care. However, the relative importance of depression severity in predicting QoL remains unclear because of few methodologically sound studies. Objectives To examine whether depression contributes to impairment of QoL irrespective of prognostic factors and symptom burden. Methods A total of 563 patients were included from the European Palliative Care Research Collaborative–Computerized Symptom Assessment Study, an international, multi-center, cross-sectional study. The relative importance of prognostic factors (systemic inflammation [modified Glasgow Prognostic Score—mGPS]), co-morbidities and physical performance (Karnofsky Performance Status), symptom burden (loss of appetite, breathlessness, nausea [Edmonton Symptom Assessment Scale], and pain [Brief Pain Inventory]), and depression severity (Patient Health Questionnaire 9) in predicting Global Health/QoL (European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire [EORTC-QLQ-C30]) were assessed using hierarchical multiple regression models. Results Fifty-five percent were women, median age was 64 years, 87% had metastatic disease, median Karnofsky Performance Status was 70, and mean global QoL was 50.5 (SD = 23.3). Worse QoL was associated with increased systemic inflammation (mGPS = 1 β = −0.12, P = 0.003; mGPS = 2 β = −0.09, P = 0.023), lower physical performance (β = 0.17, P < 0.001), reduced appetite (β = −0.15, P < 0.001), breathlessness (β = −0.11, P = 0.004), pain (β = −0.14, P = 0.002), and higher depression severity (β = −0.27, P < 0.001). The full model accounted for 29% of the observed variance in QoL scores. The strongest predictor was depression severity, accounting for 5.8% of the variance. Conclusion Depression severity was the strongest single predictor of poorer QoL in this sample of patients with advanced cancer, after accounting for a wide range of clinically relevant variables. Future studies should investigate the contribution of psychosocial variables on QoL. Our findings emphasize the importance of managing depression to achieve the best possible QoL for these patients.

Original languageEnglish
Pages (from-to)889-897
Number of pages9
JournalJournal of Pain and Symptom Management
Volume54
Issue number6
DOIs
Publication statusPublished - Dec 1 2017

Fingerprint

Quality of Life
Depression
Neoplasms
Karnofsky Performance Status
Symptom Assessment
Appetite
Pain
Dyspnea
Inflammation
Palliative Care
Research
Nausea
Cross-Sectional Studies
Organizations
Morbidity
Equipment and Supplies
Health

Keywords

  • advanced cancer
  • Depression
  • population study
  • prognosis
  • quality of life

ASJC Scopus subject areas

  • Nursing(all)
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

Cite this

Grotmol, K. S., Lie, H. C., Hjermstad, M. J., Aass, N., Currow, D., Kaasa, S., ... European Palliative Care Research Collaborative (EPCRC) (2017). Depression—A Major Contributor to Poor Quality of Life in Patients With Advanced Cancer. Journal of Pain and Symptom Management, 54(6), 889-897. https://doi.org/10.1016/j.jpainsymman.2017.04.010

Depression—A Major Contributor to Poor Quality of Life in Patients With Advanced Cancer. / Grotmol, Kjersti S.; Lie, Hanne C.; Hjermstad, Marianne J.; Aass, Nina; Currow, David; Kaasa, Stein; Moum, Torbjørn; Pigni, Alessandra; Loge, Jon Håvard; European Palliative Care Research Collaborative (EPCRC).

In: Journal of Pain and Symptom Management, Vol. 54, No. 6, 01.12.2017, p. 889-897.

Research output: Contribution to journalArticle

Grotmol, KS, Lie, HC, Hjermstad, MJ, Aass, N, Currow, D, Kaasa, S, Moum, T, Pigni, A, Loge, JH & European Palliative Care Research Collaborative (EPCRC) 2017, 'Depression—A Major Contributor to Poor Quality of Life in Patients With Advanced Cancer', Journal of Pain and Symptom Management, vol. 54, no. 6, pp. 889-897. https://doi.org/10.1016/j.jpainsymman.2017.04.010
Grotmol, Kjersti S. ; Lie, Hanne C. ; Hjermstad, Marianne J. ; Aass, Nina ; Currow, David ; Kaasa, Stein ; Moum, Torbjørn ; Pigni, Alessandra ; Loge, Jon Håvard ; European Palliative Care Research Collaborative (EPCRC). / Depression—A Major Contributor to Poor Quality of Life in Patients With Advanced Cancer. In: Journal of Pain and Symptom Management. 2017 ; Vol. 54, No. 6. pp. 889-897.
@article{e5eef278391047a78702cb284c69a6e9,
title = "Depression—A Major Contributor to Poor Quality of Life in Patients With Advanced Cancer",
abstract = "Context Quality of life (QoL) and depression are important patient-reported outcomes in cancer care. However, the relative importance of depression severity in predicting QoL remains unclear because of few methodologically sound studies. Objectives To examine whether depression contributes to impairment of QoL irrespective of prognostic factors and symptom burden. Methods A total of 563 patients were included from the European Palliative Care Research Collaborative–Computerized Symptom Assessment Study, an international, multi-center, cross-sectional study. The relative importance of prognostic factors (systemic inflammation [modified Glasgow Prognostic Score—mGPS]), co-morbidities and physical performance (Karnofsky Performance Status), symptom burden (loss of appetite, breathlessness, nausea [Edmonton Symptom Assessment Scale], and pain [Brief Pain Inventory]), and depression severity (Patient Health Questionnaire 9) in predicting Global Health/QoL (European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire [EORTC-QLQ-C30]) were assessed using hierarchical multiple regression models. Results Fifty-five percent were women, median age was 64 years, 87{\%} had metastatic disease, median Karnofsky Performance Status was 70, and mean global QoL was 50.5 (SD = 23.3). Worse QoL was associated with increased systemic inflammation (mGPS = 1 β = −0.12, P = 0.003; mGPS = 2 β = −0.09, P = 0.023), lower physical performance (β = 0.17, P < 0.001), reduced appetite (β = −0.15, P < 0.001), breathlessness (β = −0.11, P = 0.004), pain (β = −0.14, P = 0.002), and higher depression severity (β = −0.27, P < 0.001). The full model accounted for 29{\%} of the observed variance in QoL scores. The strongest predictor was depression severity, accounting for 5.8{\%} of the variance. Conclusion Depression severity was the strongest single predictor of poorer QoL in this sample of patients with advanced cancer, after accounting for a wide range of clinically relevant variables. Future studies should investigate the contribution of psychosocial variables on QoL. Our findings emphasize the importance of managing depression to achieve the best possible QoL for these patients.",
keywords = "advanced cancer, Depression, population study, prognosis, quality of life",
author = "Grotmol, {Kjersti S.} and Lie, {Hanne C.} and Hjermstad, {Marianne J.} and Nina Aass and David Currow and Stein Kaasa and Torbj{\o}rn Moum and Alessandra Pigni and Loge, {Jon H{\aa}vard} and {European Palliative Care Research Collaborative (EPCRC)}",
year = "2017",
month = "12",
day = "1",
doi = "10.1016/j.jpainsymman.2017.04.010",
language = "English",
volume = "54",
pages = "889--897",
journal = "Journal of Pain and Symptom Management",
issn = "0885-3924",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Depression—A Major Contributor to Poor Quality of Life in Patients With Advanced Cancer

AU - Grotmol, Kjersti S.

AU - Lie, Hanne C.

AU - Hjermstad, Marianne J.

AU - Aass, Nina

AU - Currow, David

AU - Kaasa, Stein

AU - Moum, Torbjørn

AU - Pigni, Alessandra

AU - Loge, Jon Håvard

AU - European Palliative Care Research Collaborative (EPCRC)

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Context Quality of life (QoL) and depression are important patient-reported outcomes in cancer care. However, the relative importance of depression severity in predicting QoL remains unclear because of few methodologically sound studies. Objectives To examine whether depression contributes to impairment of QoL irrespective of prognostic factors and symptom burden. Methods A total of 563 patients were included from the European Palliative Care Research Collaborative–Computerized Symptom Assessment Study, an international, multi-center, cross-sectional study. The relative importance of prognostic factors (systemic inflammation [modified Glasgow Prognostic Score—mGPS]), co-morbidities and physical performance (Karnofsky Performance Status), symptom burden (loss of appetite, breathlessness, nausea [Edmonton Symptom Assessment Scale], and pain [Brief Pain Inventory]), and depression severity (Patient Health Questionnaire 9) in predicting Global Health/QoL (European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire [EORTC-QLQ-C30]) were assessed using hierarchical multiple regression models. Results Fifty-five percent were women, median age was 64 years, 87% had metastatic disease, median Karnofsky Performance Status was 70, and mean global QoL was 50.5 (SD = 23.3). Worse QoL was associated with increased systemic inflammation (mGPS = 1 β = −0.12, P = 0.003; mGPS = 2 β = −0.09, P = 0.023), lower physical performance (β = 0.17, P < 0.001), reduced appetite (β = −0.15, P < 0.001), breathlessness (β = −0.11, P = 0.004), pain (β = −0.14, P = 0.002), and higher depression severity (β = −0.27, P < 0.001). The full model accounted for 29% of the observed variance in QoL scores. The strongest predictor was depression severity, accounting for 5.8% of the variance. Conclusion Depression severity was the strongest single predictor of poorer QoL in this sample of patients with advanced cancer, after accounting for a wide range of clinically relevant variables. Future studies should investigate the contribution of psychosocial variables on QoL. Our findings emphasize the importance of managing depression to achieve the best possible QoL for these patients.

AB - Context Quality of life (QoL) and depression are important patient-reported outcomes in cancer care. However, the relative importance of depression severity in predicting QoL remains unclear because of few methodologically sound studies. Objectives To examine whether depression contributes to impairment of QoL irrespective of prognostic factors and symptom burden. Methods A total of 563 patients were included from the European Palliative Care Research Collaborative–Computerized Symptom Assessment Study, an international, multi-center, cross-sectional study. The relative importance of prognostic factors (systemic inflammation [modified Glasgow Prognostic Score—mGPS]), co-morbidities and physical performance (Karnofsky Performance Status), symptom burden (loss of appetite, breathlessness, nausea [Edmonton Symptom Assessment Scale], and pain [Brief Pain Inventory]), and depression severity (Patient Health Questionnaire 9) in predicting Global Health/QoL (European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire [EORTC-QLQ-C30]) were assessed using hierarchical multiple regression models. Results Fifty-five percent were women, median age was 64 years, 87% had metastatic disease, median Karnofsky Performance Status was 70, and mean global QoL was 50.5 (SD = 23.3). Worse QoL was associated with increased systemic inflammation (mGPS = 1 β = −0.12, P = 0.003; mGPS = 2 β = −0.09, P = 0.023), lower physical performance (β = 0.17, P < 0.001), reduced appetite (β = −0.15, P < 0.001), breathlessness (β = −0.11, P = 0.004), pain (β = −0.14, P = 0.002), and higher depression severity (β = −0.27, P < 0.001). The full model accounted for 29% of the observed variance in QoL scores. The strongest predictor was depression severity, accounting for 5.8% of the variance. Conclusion Depression severity was the strongest single predictor of poorer QoL in this sample of patients with advanced cancer, after accounting for a wide range of clinically relevant variables. Future studies should investigate the contribution of psychosocial variables on QoL. Our findings emphasize the importance of managing depression to achieve the best possible QoL for these patients.

KW - advanced cancer

KW - Depression

KW - population study

KW - prognosis

KW - quality of life

UR - http://www.scopus.com/inward/record.url?scp=85035778436&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85035778436&partnerID=8YFLogxK

U2 - 10.1016/j.jpainsymman.2017.04.010

DO - 10.1016/j.jpainsymman.2017.04.010

M3 - Article

AN - SCOPUS:85035778436

VL - 54

SP - 889

EP - 897

JO - Journal of Pain and Symptom Management

JF - Journal of Pain and Symptom Management

SN - 0885-3924

IS - 6

ER -