Depressive symptoms and schizophrenic relapses: The effect of four neuroleptic drugs

Massimo C. Mauri, Antonella Bitetto, Lorenza Fabiano, Valerio Laini, Clara Steinhilber, Monica Fornier, Farouk Rafique

Research output: Contribution to journalArticlepeer-review


1. A prevalence of depressive symptomatology, ranging from 25% to 80% has been reported during the course of schizophrenia. 2. Depressive symptoms were assessed in 144 schizophrenic patients (DSM IV) during an acute exacerbation phase. 3. Depressive symptoms showed a prevalence ranging from 5.5% (severe clinical pictures) to 54.8 % (mild clinical pictures). 4. The authors did not find a correlation between depressive symptoms per se and the presence of negative psychotic symptoms. Depression may be linked not so much to negative symptoms but to the psychotic state itself. 5. Depressive symptomatology concurrently occured with schizophrenic relapses and improved together with the psychotic clinical picture, independently of the neuroleptic drug employed. Haloperidol, haloperidol decanoate and fluphenazine decanoate all showed a similar improvement of depressive symptoms. 6. L-sulpiride showed a trend to be most effective on depressive symptomatology in comparison to the other neuroleptics.

Original languageEnglish
Pages (from-to)43-54
Number of pages12
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Issue number1
Publication statusPublished - Jan 1999


  • Depression
  • Negative symptoms
  • Neuroleptic treatment
  • Schizophrenia

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology


Dive into the research topics of 'Depressive symptoms and schizophrenic relapses: The effect of four neuroleptic drugs'. Together they form a unique fingerprint.

Cite this