Depressive symptoms combined with dementia affect 12-months survival in elderly patients after rehabilitation post-hip fracture surgery

Giuseppe Bellelli, Giovanni B. Frisoni, Renato Turco, Marco Trabucchi

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Objectives: To assess whether the association of depression and dementia affects 12-month survival of elderly patients after rehabilitation post-hip fracture (HF) surgery. Methods: Two hundred eleven inpatients admitted to a Rehabilitation and Aged Care Unit (RACU) following surgery for HF were screened for depression with the 15-item Geriatric Depression Scale (GDS) and stratified into four groups according to dementia (n=40), depressive symptoms (n=54, GDS score>7/15), both (n=27), and neither conditions (n=90). The 12-months survival after discharge was assessed among groups with Kaplan Meyer analysis and compared with Cox proportional hazard regression models adjusted for covariates. Subjects with neither depression nor dementia were the reference group. Results: Survival of patients with depression and dementia was significantly lower than the other 3 groups: after adjustment for age, gender, comorbidity (Charlson Index), use of antidepressants, and Barthel Index at discharge, their Hazard Ratio (HR) was 8.7 (95% CI 1.5-48.5; p=0.01); in the same Cox regression model, the HR of patients with dementia alone was 3.4 (95% CI 0.5-24.0; p=0.20) while the HR of patients with depressive symptoms but no dementia was 5.0 (95% CI 0.8-28.3; p=0.07). Conclusions: The co-occurrence of depression and dementia significantly increases the 12-months risk of dying in elderly patients after rehabilitation post-HF surgery.

Original languageEnglish
Pages (from-to)1073-1077
Number of pages5
JournalInternational Journal of Geriatric Psychiatry
Volume23
Issue number10
DOIs
Publication statusPublished - 2008

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Hip Fractures
Dementia
Rehabilitation
Depression
Survival
Proportional Hazards Models
Geriatrics
Antidepressive Agents
Comorbidity
Inpatients

Keywords

  • Dementia
  • Depression
  • Hip fracture
  • Mortality

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Depressive symptoms combined with dementia affect 12-months survival in elderly patients after rehabilitation post-hip fracture surgery. / Bellelli, Giuseppe; Frisoni, Giovanni B.; Turco, Renato; Trabucchi, Marco.

In: International Journal of Geriatric Psychiatry, Vol. 23, No. 10, 2008, p. 1073-1077.

Research output: Contribution to journalArticle

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abstract = "Objectives: To assess whether the association of depression and dementia affects 12-month survival of elderly patients after rehabilitation post-hip fracture (HF) surgery. Methods: Two hundred eleven inpatients admitted to a Rehabilitation and Aged Care Unit (RACU) following surgery for HF were screened for depression with the 15-item Geriatric Depression Scale (GDS) and stratified into four groups according to dementia (n=40), depressive symptoms (n=54, GDS score>7/15), both (n=27), and neither conditions (n=90). The 12-months survival after discharge was assessed among groups with Kaplan Meyer analysis and compared with Cox proportional hazard regression models adjusted for covariates. Subjects with neither depression nor dementia were the reference group. Results: Survival of patients with depression and dementia was significantly lower than the other 3 groups: after adjustment for age, gender, comorbidity (Charlson Index), use of antidepressants, and Barthel Index at discharge, their Hazard Ratio (HR) was 8.7 (95{\%} CI 1.5-48.5; p=0.01); in the same Cox regression model, the HR of patients with dementia alone was 3.4 (95{\%} CI 0.5-24.0; p=0.20) while the HR of patients with depressive symptoms but no dementia was 5.0 (95{\%} CI 0.8-28.3; p=0.07). Conclusions: The co-occurrence of depression and dementia significantly increases the 12-months risk of dying in elderly patients after rehabilitation post-HF surgery.",
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