Abstract
Background: Depression occurs in about 50% of patients with multiple sclerosis. The aims of this study was to investigate the prevalence of depressive symptoms in a multicenterMS population using the Beck Depression Inventory II (BDI II) and to identify possible correlations between the BDI II score and demographic and clinical variables. Methods: Data were collected in a multi-center, cross-sectional study over a period of six months in six MS centers in Italy using BDI II. Results: 1,011 MS patients participated in the study. 676 subjects were female, with a mean age of 34 years (SD 10.8), mean EDSS of 3.3 (0-8.5) and mean disease duration of 10.3 years (range 1-50 years). 668 (%) subjects scored lower than 14 on the BDI II and 343 (33.9%) scored greater than 14 (14 cut-off score). For patients with BDI>14 multivariate analysis showed a significant difference between EDSS and disease course. BDI II scores for subjects with secondary progressive (SP) MS were significantly different from primary progressive (PP) patients (p < 0.001) but similar to relapsing-remitting (RR) patients. Considering subjects with moderate to severe depressive symptoms (BDI II score from 20-63), in relation to disease course, 11.7% (83/710) had RR MS, 40.7% (96/236) SP and 13.6% (6/44) PP. Conclusions: Using the BDI II, 30% of the current sample had depressive symptoms. BDI II score correlates with disability and disease course, particularly in subjects with SP MS. The BDI II scale can be a useful tool in clinical practice to screen depressive symptoms in people with MS.
| Original language | English |
|---|---|
| Article number | e0160261 |
| Journal | PLoS One |
| Volume | 11 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sep 1 2016 |
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ASJC Scopus subject areas
- Medicine(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Agricultural and Biological Sciences(all)
Cite this
Depressive symptoms correlate with disability and disease course in multiple sclerosis patients : An Italian multi-center study using the Beck Depression Inventory. / Solaro, Claudio; Trabucco, Erika; Signori, A.; Martinelli, Vittorio; Radaelli, M.; Centonze, Diego; Rossi, Silvia; Grasso, Maria Grazia; Clemenzi, Alessandro; Bonavita, Simona; D'Ambrosio, A.; Patti, Francesco; D'Amico, Emanuele; Cruccu, G.; Truini, A.
In: PLoS One, Vol. 11, No. 9, e0160261, 01.09.2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Depressive symptoms correlate with disability and disease course in multiple sclerosis patients
T2 - An Italian multi-center study using the Beck Depression Inventory
AU - Solaro, Claudio
AU - Trabucco, Erika
AU - Signori, A.
AU - Martinelli, Vittorio
AU - Radaelli, M.
AU - Centonze, Diego
AU - Rossi, Silvia
AU - Grasso, Maria Grazia
AU - Clemenzi, Alessandro
AU - Bonavita, Simona
AU - D'Ambrosio, A.
AU - Patti, Francesco
AU - D'Amico, Emanuele
AU - Cruccu, G.
AU - Truini, A.
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Background: Depression occurs in about 50% of patients with multiple sclerosis. The aims of this study was to investigate the prevalence of depressive symptoms in a multicenterMS population using the Beck Depression Inventory II (BDI II) and to identify possible correlations between the BDI II score and demographic and clinical variables. Methods: Data were collected in a multi-center, cross-sectional study over a period of six months in six MS centers in Italy using BDI II. Results: 1,011 MS patients participated in the study. 676 subjects were female, with a mean age of 34 years (SD 10.8), mean EDSS of 3.3 (0-8.5) and mean disease duration of 10.3 years (range 1-50 years). 668 (%) subjects scored lower than 14 on the BDI II and 343 (33.9%) scored greater than 14 (14 cut-off score). For patients with BDI>14 multivariate analysis showed a significant difference between EDSS and disease course. BDI II scores for subjects with secondary progressive (SP) MS were significantly different from primary progressive (PP) patients (p < 0.001) but similar to relapsing-remitting (RR) patients. Considering subjects with moderate to severe depressive symptoms (BDI II score from 20-63), in relation to disease course, 11.7% (83/710) had RR MS, 40.7% (96/236) SP and 13.6% (6/44) PP. Conclusions: Using the BDI II, 30% of the current sample had depressive symptoms. BDI II score correlates with disability and disease course, particularly in subjects with SP MS. The BDI II scale can be a useful tool in clinical practice to screen depressive symptoms in people with MS.
AB - Background: Depression occurs in about 50% of patients with multiple sclerosis. The aims of this study was to investigate the prevalence of depressive symptoms in a multicenterMS population using the Beck Depression Inventory II (BDI II) and to identify possible correlations between the BDI II score and demographic and clinical variables. Methods: Data were collected in a multi-center, cross-sectional study over a period of six months in six MS centers in Italy using BDI II. Results: 1,011 MS patients participated in the study. 676 subjects were female, with a mean age of 34 years (SD 10.8), mean EDSS of 3.3 (0-8.5) and mean disease duration of 10.3 years (range 1-50 years). 668 (%) subjects scored lower than 14 on the BDI II and 343 (33.9%) scored greater than 14 (14 cut-off score). For patients with BDI>14 multivariate analysis showed a significant difference between EDSS and disease course. BDI II scores for subjects with secondary progressive (SP) MS were significantly different from primary progressive (PP) patients (p < 0.001) but similar to relapsing-remitting (RR) patients. Considering subjects with moderate to severe depressive symptoms (BDI II score from 20-63), in relation to disease course, 11.7% (83/710) had RR MS, 40.7% (96/236) SP and 13.6% (6/44) PP. Conclusions: Using the BDI II, 30% of the current sample had depressive symptoms. BDI II score correlates with disability and disease course, particularly in subjects with SP MS. The BDI II scale can be a useful tool in clinical practice to screen depressive symptoms in people with MS.
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U2 - 10.1371/journal.pone.0160261
DO - 10.1371/journal.pone.0160261
M3 - Article
VL - 11
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 9
M1 - e0160261
ER -