Depressive symptoms, neurocognitive impairment, and adherence to highly active antiretroviral therapy among HIV-infected persons

Adriana Ammassari, Andrea Antinori, Maria Stella Aloisi, Maria Paola Trotta, Rita Murri, Luca Bartoli, Antonella D'Arminio Monforte, Albert W. Wu, Fabrizio Starace

Research output: Contribution to journalArticle

197 Citations (Scopus)

Abstract

The association of depressive symptoms, neurocognitive impairment, and adherence to highly active antiretroviral therapy (HAART) was evaluated in 135 HIV-infected persons. Thirty percent reported nonadherence to HAART. Depressive symptoms (assessed with the Montgomery-Asberg Depression Rating Scale) and neurocognitive impairment (assessed with a neuropsychological test battery) were documented in 24% and 12%, respectively, of the study participants. Nonadherence to HAART was independently associated with worse depression rating scale scores (odds ratio = 1.05, 95% confidence interval [CI] = 1.00-1.10), acquisition of HIV through injection of drugs (odds ratio = 2.59, 95% CI = 1.05-6.39), and complaints about impairment of sexual activity (odds ratio = 6.62, 95% CI = 1.16-37.6). The presence of depressive symptoms, but not neurocognitive impairment, was associated with nonadherence.

Original languageEnglish
Pages (from-to)394-402
Number of pages9
JournalPsychosomatics
Volume45
Issue number5
DOIs
Publication statusPublished - Sep 2004

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Highly Active Antiretroviral Therapy
HIV
Depression
Odds Ratio
Confidence Intervals
Neuropsychological Tests
Sexual Behavior
Adherence
Depressive Symptoms
Person
Impairment
Antiretroviral Therapy
AIDS/HIV
Injections
Confidence Interval
Pharmaceutical Preparations
Rating Scales

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Psychology(all)

Cite this

Depressive symptoms, neurocognitive impairment, and adherence to highly active antiretroviral therapy among HIV-infected persons. / Ammassari, Adriana; Antinori, Andrea; Aloisi, Maria Stella; Trotta, Maria Paola; Murri, Rita; Bartoli, Luca; D'Arminio Monforte, Antonella; Wu, Albert W.; Starace, Fabrizio.

In: Psychosomatics, Vol. 45, No. 5, 09.2004, p. 394-402.

Research output: Contribution to journalArticle

Ammassari, Adriana ; Antinori, Andrea ; Aloisi, Maria Stella ; Trotta, Maria Paola ; Murri, Rita ; Bartoli, Luca ; D'Arminio Monforte, Antonella ; Wu, Albert W. ; Starace, Fabrizio. / Depressive symptoms, neurocognitive impairment, and adherence to highly active antiretroviral therapy among HIV-infected persons. In: Psychosomatics. 2004 ; Vol. 45, No. 5. pp. 394-402.
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