Depressive syndrome in major psychoses: A study on 1351 subjects

Alessandro Serretti, Laura Mandelli, Enrico Lattuada, Enrico Smeraldi

Research output: Contribution to journalArticlepeer-review


The aim of this study was to investigate depressive symptomatology across distinct major psychiatric disorders. A total of 1351 subjects affected by major depressive disorder (MDD=389), bipolar disorder (BP=511), delusional disorder (DD=93) and schizophrenia (SKZ=358) were included in our study. Subjects were assessed using the Operational Criteria for Psychotic Illness checklist (OPCRIT). The most frequently represented depressive symptoms in MDD were Loss of energy/tiredness, Loss of pleasure, Poor concentration, and Sleep disorders. Compared with MDD, BP had higher occurrences of Agitated activity, Excessive sleep, and Increased appetite and/or Weight gain, as well as lower Loss of pleasure. In our sample, 32.3% and 26.8% of DD and SKZ, respectively, had quite consistent depressive symptomatology, with at least four or more depressive symptoms. The most common depressive symptoms were Sleep disorders, Poor concentration and Loss of energy/Tiredness, followed by Psychomotor symptoms in SKZ only. Excessive self-reproach, Suicidal ideation, and Appetite and/or Weight changes were more specific to mood disorders. Finally, compared with SKZ, DD suffered from more depressive symptoms and had more severe depressive symptomatology. A quite consistent level of depressive symptomatology is therefore present in subpopulations of delusional and schizophrenic subjects other than in affective subjects. We identified some symptoms that are common across all major psychoses and symptoms that are more specific to each group.

Original languageEnglish
Pages (from-to)85-99
Number of pages15
JournalPsychiatry Research
Issue number1-2
Publication statusPublished - Jun 30 2004


  • Bipolar disorder
  • Delusional disorder
  • Depression
  • Depressive disorder
  • Schizophrenia
  • Symptomatology

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)


Dive into the research topics of 'Depressive syndrome in major psychoses: A study on 1351 subjects'. Together they form a unique fingerprint.

Cite this