Deranged Anterior Pituitary Responsiveness to Hypothalamic Hormones in Depressed Patients

Francesca Brambilla, Enrico Smeraldi, Emilio Sacchetti, Fiammetta Negri, Daniela Cocchi, Eugenio E. Müller

Research output: Contribution to journalArticle

Abstract

Abnormal anterior pituitary (AP) responsiveness to acute administration of thyrotropin-releasing hormone (TRH) and luteinizing hormone-follicle stimulating hormone-releasing hormone (LH-RH) was investigated in 14 patients (two men and 12 women) suffering from primary affective disorders. In ten, TRH, 500 μg given intravenously, induced a rise in plasma growth hormone (GH) level, while in eight patients it induced a rise in plasma levels of FSH or LH or both. When LH-RH, 150 μg was administered intravenously to ten patients, it induced a rise in plasma GH level in one patient and increased plasma prolactin level in three patients. Collectively, in only three of 14 patients was conventional AP responsiveness to hypothalamic neurohormones present. These findings demonstrate the existence of a profound derangement of AP responsiveness to hypothalamic neurohormones in depressed patients and suggest that a primary alteration in the physiologic links between the central nervous system and the AP may be at the origin of the neuroendocrine disturbance.

Original languageEnglish
Pages (from-to)1231-1238
Number of pages8
JournalArchives of General Psychiatry
Volume35
Issue number10
DOIs
Publication statusPublished - 1978

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'Deranged Anterior Pituitary Responsiveness to Hypothalamic Hormones in Depressed Patients'. Together they form a unique fingerprint.

  • Cite this

    Brambilla, F., Smeraldi, E., Sacchetti, E., Negri, F., Cocchi, D., & Müller, E. E. (1978). Deranged Anterior Pituitary Responsiveness to Hypothalamic Hormones in Depressed Patients. Archives of General Psychiatry, 35(10), 1231-1238. https://doi.org/10.1001/archpsyc.1978.01770340081009