TY - JOUR
T1 - Derangement of immune responses by myeloid suppressor cells
AU - Serafini, Paolo
AU - De Santo, Carmela
AU - Marigo, Ilaria
AU - Cingarlini, Sara
AU - Dolcetti, Luigi
AU - Gallina, Giovanna
AU - Zanovello, Paola
AU - Bronte, Vincenzo
PY - 2004/2
Y1 - 2004/2
N2 - In tumor-bearing mice and cancer patients, tumor progression is often associated with altered hematopoiesis leading to the accumulation of myeloid cells. Extensive studies in preclinical models indicate that these cells share the CD11b and the Gr-1 markers, possess a mixed mature-immature myeloid phenotype, and are responsible for the induction of T-cell dysfunctions, both tumor-specific and nonspecific. Moreover, CD11b+ Gr-1+ myeloid cells are described under different unrelated situations associated with temporary impairment of the T-lymphocyte reactivity. This review examines recent findings on the nature, properties, and mechanisms of action of these myeloid suppressor cells (MSCs).
AB - In tumor-bearing mice and cancer patients, tumor progression is often associated with altered hematopoiesis leading to the accumulation of myeloid cells. Extensive studies in preclinical models indicate that these cells share the CD11b and the Gr-1 markers, possess a mixed mature-immature myeloid phenotype, and are responsible for the induction of T-cell dysfunctions, both tumor-specific and nonspecific. Moreover, CD11b+ Gr-1+ myeloid cells are described under different unrelated situations associated with temporary impairment of the T-lymphocyte reactivity. This review examines recent findings on the nature, properties, and mechanisms of action of these myeloid suppressor cells (MSCs).
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U2 - 10.1007/s00262-003-0443-2
DO - 10.1007/s00262-003-0443-2
M3 - Article
C2 - 14593498
AN - SCOPUS:0742286811
VL - 53
SP - 64
EP - 72
JO - Cancer Immunology and Immunotherapy
JF - Cancer Immunology and Immunotherapy
SN - 0340-7004
IS - 2
ER -