Deregulated human glioma cell motility: Inhibitory effect of somatostatin

Maria Grazia Cattaneo, Davide Gentilini, Lucia Maria Vicentini

Research output: Contribution to journalArticlepeer-review

Abstract

Malignant gliomas are highly invasive tumors which are lethal despite aggressive therapy. The motility behavior of two human glioma cell lines i.e. T98G and U87-MG cells was analysed. The glioma cells showed a high degree of basal motility (especially U87-MG cells) that may be related to the considerable local invasiveness of such tumours even in the absence of exogenous factors. The two cell lines responded equally well to platelet-derived growth factor (PDGF) as chemoattractant factor. The phosphatidylinositol 3-kinase (PI3-K) signaling, but not the extracellular signal-related kinase (ERK) signaling, was strongly involved in the PDGF-stimulated glioma cell motility. Somatostatin was capable of inhibiting the migration in both glioma cell lines without affecting crucial targets for motility control like PI3-K and Rac activity. These data suggest that somatostatin, by interfering with a target further downstream to Rac, negatively affects glioma cell motility, and may thus offer a pharmacological approach to controlling the deregulated motility of these aggressive tumoral cells.

Original languageEnglish
Pages (from-to)34-39
Number of pages6
JournalMolecular and Cellular Endocrinology
Volume256
Issue number1-2
DOIs
Publication statusPublished - Aug 15 2006

Keywords

  • Human tumoral cells
  • Intracellular pathways
  • Invasiveness
  • Migration
  • Somatostatin

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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