Deregulated miRNAs in bone health: Epigenetic roles in osteoporosis

Research output: Contribution to journalReview articlepeer-review

Abstract

MicroRNA (miRNA) has shown to enhance or inhibit cell proliferation, differentiation and activity of different cell types in bone tissue. The discovery of miRNA actions and their targets has helped to identify them as novel regulations actors in bone. Various studies have shown that miRNA deregulation mediates the progression of bone-related pathologies, such as osteoporosis. The present review intends to give an exhaustive overview of miRNAs with experimentally validated targets involved in bone homeostasis and highlight their possible role in osteoporosis development. Moreover, the review analyzes miRNAs identified in clinical trials and involved in osteoporosis.

Original languageEnglish
Pages (from-to)52-75
Number of pages24
JournalBone
Volume122
Early online dateFeb 14 2019
DOIs
Publication statusPublished - May 2019

Keywords

  • Osteoblast
  • Osteoclast
  • Osteogenesis
  • Osteoporosis
  • miRNA

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