Deregulated miRNAs in osteoporosis: effects in bone metastasis

Daniele Bellavia, Francesca Salamanna, Lavinia Raimondi, Angela De Luca, Valeria Carina, Viviana Costa, R Alessandro, Milena Fini, Gianluca Giavaresi

Research output: Contribution to journalReview article

Abstract

Starting from their role exerted on osteoblast and osteoclast differentiation and activity pathways, microRNAs (miRNAs) have been recently identified as regulators of different processes in bone homeostasis. For this purpose, in a recent review, we highlighted, as deregulated miRNAs could be involved in different bone diseases such as osteoporosis. In addition, recent studies supported the concept that osteoporosis-induced bone alterations might offer a receptive site for cancer cells to form bone metastases, However, to date, no data on specific-shared miRNAs between osteoporosis and bone metastases have been considered and described to clarify the evidence of this link. The main goal of this review is to underline as deregulated miRNAs in osteoporosis may have specific roles in the development of bone metastases. The review showed that several circulating osteoporotic miRNAs could facilitate tumor progression and bone-metastasis formation in several tumor types, i.e., breast cancer, prostate cancer, non-small-cell lung cancer, esophageal squamous cell carcinoma, and multiple myeloma. In detail, serum up-regulation of pro-osteoporotic miRNAs, as well as serum down-regulation of anti-osteoporotic miRNAs are common features of all these tumors and are able to promote bone metastasis. These results are of key importance and could help researcher and clinicians to establish new therapeutic strategies connected with deregulation of circulating miRNAs and able to interfere with pathogenic processes of osteoporosis, tumor progressions, and bone-metastasis formation.

Original languageEnglish
Pages (from-to)3723-3744
Number of pages22
JournalCellular and Molecular Life Sciences
Volume76
DOIs
Publication statusE-pub ahead of print - May 30 2019

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Keywords

  • Bone metastasis
  • Osteolysis
  • Osteoporosis
  • miRNA

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