Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma

Shinsuke Iida, Pulivarthi H. Rao, Marion Butler, Paolo Corradini, Mario Boccadoro, Bernard Klein, R. S K Chaganti, Riccardo Dalla-Favera

Research output: Contribution to journalLetter

Abstract

The pathogenesis of multiple myeloma (MM), an incurable a tumour causing the deregulated proliferation of terminally differentiated B cells, is unknown1. Chromosomal translocations (14q1) affecting band 14q32 and unidentified partner chromosomes are common in this tumour, suggesting that they may cause the activation of novel oncogenes2, 3. By cloning the chromosomal breakpoints in an MM cell line, we show that the 14q+ translocation represents a t(6;14)(p25;q32) and that this aberration is recurrent in MM, as it was found in two of eleven MM cell lines. The translocation juxtaposes the immunoglobulin heavy-chain (IgH) locus to MUM1 (multiple myeloma oncogene 1)IRF4 gene, a member of the interferon regulatory factor (IRF) family known to be active in the control of B-cell proliferation and differentiation. As a result, the MUM1/IRF4 gene is overexpressed-an event that may contribute to tumorigenesis, as MUM1/IRF4 has oncogenic activity in vitro. These findings identify a novel genetic alteration associated with MM, with implications for the pathogenesis and diagnostics of this tumour.

Original languageEnglish
Pages (from-to)230
Number of pages1
JournalNature Genetics
Volume17
Issue number2
DOIs
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Medicine(all)
  • Genetics

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    Iida, S., Rao, P. H., Butler, M., Corradini, P., Boccadoro, M., Klein, B., Chaganti, R. S. K., & Dalla-Favera, R. (1997). Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma. Nature Genetics, 17(2), 230. https://doi.org/10.1038/ng1097-226