Derivation and Validation of a Scoring System to Identify Patients with Bacteremia and Hematological Malignancies at Higher Risk for Mortality

Mario Tumbarello, Enrico Maria Trecarichi, Morena Caira, Anna Candoni, Domenico Pastore, Chiara Cattaneo, Rosa Fanci, Annamaria Nosari, Antonio Spadea, Alessandro Busca, Nicola Vianelli, Teresa Spanu, Livio Pagano

Research output: Contribution to journalArticle

Abstract

Background: The aim of this study was to develop and validate a reliable clinical prediction rule that could be employed to identify patients at higher likelihood of mortality among those with hematological malignancies (HMs) and bacterial bloodstream infections (BBSIs). Methods and Findings: We conducted a retrospective cohort study in nine Italian hematological units. The derivation cohort consisted of adult patients with BBSI and HMs admitted to the Catholic University Hospital (Rome) between January 2002 and December 2008. Survivors and nonsurvivors were compared to identify predictors of 30-day mortality. The validation cohort consisted of patients hospitalized with BBSI and HMs who were admitted in 8 other Italian hematological units between January 2009 and December 2010. The inclusion and exclusion criteria were identical for both cohorts, with type and stage of HMs used as matching criteria. In the derivation set (247 episodes), the multivariate analysis yielded the following significant mortality-related risk factors acute renal failure (Odds Ratio [OR] 6.44, Confidential Interval [CI], 2.36-17.57, P3) (OR 4.38, CI, 2.04-9.43, P

Original languageEnglish
Article numbere51612
JournalPLoS One
Volume7
Issue number12
DOIs
Publication statusPublished - Dec 14 2012

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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