TY - JOUR
T1 - Derivation and Validation of a Scoring System to Identify Patients with Bacteremia and Hematological Malignancies at Higher Risk for Mortality
AU - Tumbarello, Mario
AU - Trecarichi, Enrico Maria
AU - Caira, Morena
AU - Candoni, Anna
AU - Pastore, Domenico
AU - Cattaneo, Chiara
AU - Fanci, Rosa
AU - Nosari, Annamaria
AU - Spadea, Antonio
AU - Busca, Alessandro
AU - Vianelli, Nicola
AU - Spanu, Teresa
AU - Pagano, Livio
PY - 2012/12/14
Y1 - 2012/12/14
N2 - Background: The aim of this study was to develop and validate a reliable clinical prediction rule that could be employed to identify patients at higher likelihood of mortality among those with hematological malignancies (HMs) and bacterial bloodstream infections (BBSIs). Methods and Findings: We conducted a retrospective cohort study in nine Italian hematological units. The derivation cohort consisted of adult patients with BBSI and HMs admitted to the Catholic University Hospital (Rome) between January 2002 and December 2008. Survivors and nonsurvivors were compared to identify predictors of 30-day mortality. The validation cohort consisted of patients hospitalized with BBSI and HMs who were admitted in 8 other Italian hematological units between January 2009 and December 2010. The inclusion and exclusion criteria were identical for both cohorts, with type and stage of HMs used as matching criteria. In the derivation set (247 episodes), the multivariate analysis yielded the following significant mortality-related risk factors acute renal failure (Odds Ratio [OR] 6.44, Confidential Interval [CI], 2.36-17.57, P3) (OR 4.38, CI, 2.04-9.43, P
AB - Background: The aim of this study was to develop and validate a reliable clinical prediction rule that could be employed to identify patients at higher likelihood of mortality among those with hematological malignancies (HMs) and bacterial bloodstream infections (BBSIs). Methods and Findings: We conducted a retrospective cohort study in nine Italian hematological units. The derivation cohort consisted of adult patients with BBSI and HMs admitted to the Catholic University Hospital (Rome) between January 2002 and December 2008. Survivors and nonsurvivors were compared to identify predictors of 30-day mortality. The validation cohort consisted of patients hospitalized with BBSI and HMs who were admitted in 8 other Italian hematological units between January 2009 and December 2010. The inclusion and exclusion criteria were identical for both cohorts, with type and stage of HMs used as matching criteria. In the derivation set (247 episodes), the multivariate analysis yielded the following significant mortality-related risk factors acute renal failure (Odds Ratio [OR] 6.44, Confidential Interval [CI], 2.36-17.57, P3) (OR 4.38, CI, 2.04-9.43, P
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U2 - 10.1371/journal.pone.0051612
DO - 10.1371/journal.pone.0051612
M3 - Article
C2 - 23272123
AN - SCOPUS:84871290963
VL - 7
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 12
M1 - e51612
ER -