Dermal exposure and risk assessment of tebuconazole applicators in vineyards

S. Mandic-Rajcevic, F. M. Rubino, G. Vianello, L. Fugnoli, Elisa Polledri, Rosa Mercadante, A. Moretto, Silvia Fustinoni, C. Colosio

Research output: Contribution to journalArticlepeer-review


Introduction: Models used in the pre-marketing evaluation do not cover all work scenarios and may over-or underestimate exposure. Objectives: Uncertainties present in the extrapolation from pre-marketing to the post-marketing warrant exposure and risk assessment in real-life working conditions. Methods: Seven vineyard pesticide applicators were followed for a total of 12 work-days. A data collection sheet was developed specifically for this study. Workers' body exposure, hands, and head exposure were measured. Tebuconazole was analyzed using LCMS/ MS. Results: Median potential and actual body exposures were 22.41 mg/kg and 0.49 mg/kg of active substance applied, respectively. The median protection factor provided by the coverall was 98% (range: 90-99%). Hand exposure was responsible for 61% of total actual exposure, and was reduced by more than 50% in workers using gloves. The German Model underestimated the exposure in one work-day, and grossly overestimated it in 3 workdays. Conclusions: High levels of potential body exposure were efficiently controlled by the cotton coverall. Use of personal protective devices, especially chemically-resistant gloves and head cover is the main determinant of skin protection. Field studies on pesticide exposure in real-life conditions and development of methods and tools for easier risk assessment are necessary to complement and confirm the risk assessment done in the authorization process.

Original languageEnglish
Pages (from-to)294-315
Number of pages22
JournalMedicina del Lavoro
Issue number4
Publication statusPublished - 2015


  • Conazoles
  • dermal dosimetry
  • pesticide application

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Medicine(all)


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