Dermatofibrosarcoma protuberans: when the age makes the difference

Giovanni Paolino; Dario Didona; Ugo Bottoni; Federico Romaniello; Paola Corsetti; Antonio G Richetta; Stefano Calvieri

doi:10.23736/S0392-0488.17.05435-9

Dermatofibrosarcoma protuberans: when the age makes the difference

Giovanni Paolino, Dario Didona, Ugo Bottoni, Federico Romaniello, Paola Corsetti, Antonio G Richetta, Stefano Calvieri

Istituto Dermopatico dell'Immacolata , IDI

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Dermatofibrosarcoma protuberans is a malignant tumor that affects exclusively the skin. It is a low- grade malignant tumor of subcutaneous tissues, characterized by a local recurrence but it seldom metastasizes. This study aims to evaluate the impact of different clinical parameters on disease free survival and overall survival of dermatofibrosarcoma protuberans patients.

METHODS: A retrospective study of data including 17 cases of dermatofibrosarcoma protuberans (11 male, 6 female) retrieved from the files of the Dermatology Clinics of La Sapienza, University of Rome. We evaluated three clinical parameters (age, sex and anatomic site of the primary tumor) using the Kaplan- Meier product and the log-rank test.

RESULTS: The results highlighted that patients with an age ≤ 49 years showed a median disease free survival of 36 months, while patients with an age ≥50 years of 4 months (p < 0.0003). In addition, performing Rank- correlation, only the variable age (p< 0.0001) reached the statistical significance. Regarding overall survival, performing Rank-correlation only the variable age reached the statistical significance (p= 0.02).

CONCLUSIONS: Our data suggests that age has a statistically significant role on disease free survival and overall survival of dermatofibrosarcoma protuberans patients.

Original language	English
Journal	Giornale Italiano di Dermatologia e Venereologia
DOIs	https://doi.org/10.23736/S0392-0488.17.05435-9
Publication status	E-pub ahead of print - May 16 2017

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@article{3e036f11d26c4927942e729bd7116c2e,

title = "Dermatofibrosarcoma protuberans: when the age makes the difference",

abstract = "BACKGROUND: Dermatofibrosarcoma protuberans is a malignant tumor that affects exclusively the skin. It is a low- grade malignant tumor of subcutaneous tissues, characterized by a local recurrence but it seldom metastasizes. This study aims to evaluate the impact of different clinical parameters on disease free survival and overall survival of dermatofibrosarcoma protuberans patients.METHODS: A retrospective study of data including 17 cases of dermatofibrosarcoma protuberans (11 male, 6 female) retrieved from the files of the Dermatology Clinics of La Sapienza, University of Rome. We evaluated three clinical parameters (age, sex and anatomic site of the primary tumor) using the Kaplan- Meier product and the log-rank test.RESULTS: The results highlighted that patients with an age ≤ 49 years showed a median disease free survival of 36 months, while patients with an age ≥50 years of 4 months (p < 0.0003). In addition, performing Rank- correlation, only the variable age (p< 0.0001) reached the statistical significance. Regarding overall survival, performing Rank-correlation only the variable age reached the statistical significance (p= 0.02).CONCLUSIONS: Our data suggests that age has a statistically significant role on disease free survival and overall survival of dermatofibrosarcoma protuberans patients.",

author = "Giovanni Paolino and Dario Didona and Ugo Bottoni and Federico Romaniello and Paola Corsetti and Richetta, {Antonio G} and Stefano Calvieri",

year = "2017",

month = may,

day = "16",

doi = "10.23736/S0392-0488.17.05435-9",

language = "English",

journal = "Giornale Italiano di Dermatologia e Venereologia",

issn = "0392-0488",

publisher = "Edizioni Minerva Medica S.p.A.",

}

TY - JOUR

T1 - Dermatofibrosarcoma protuberans

T2 - when the age makes the difference

AU - Paolino, Giovanni

AU - Didona, Dario

AU - Bottoni, Ugo

AU - Romaniello, Federico

AU - Corsetti, Paola

AU - Richetta, Antonio G

AU - Calvieri, Stefano

PY - 2017/5/16

Y1 - 2017/5/16

N2 - BACKGROUND: Dermatofibrosarcoma protuberans is a malignant tumor that affects exclusively the skin. It is a low- grade malignant tumor of subcutaneous tissues, characterized by a local recurrence but it seldom metastasizes. This study aims to evaluate the impact of different clinical parameters on disease free survival and overall survival of dermatofibrosarcoma protuberans patients.METHODS: A retrospective study of data including 17 cases of dermatofibrosarcoma protuberans (11 male, 6 female) retrieved from the files of the Dermatology Clinics of La Sapienza, University of Rome. We evaluated three clinical parameters (age, sex and anatomic site of the primary tumor) using the Kaplan- Meier product and the log-rank test.RESULTS: The results highlighted that patients with an age ≤ 49 years showed a median disease free survival of 36 months, while patients with an age ≥50 years of 4 months (p < 0.0003). In addition, performing Rank- correlation, only the variable age (p< 0.0001) reached the statistical significance. Regarding overall survival, performing Rank-correlation only the variable age reached the statistical significance (p= 0.02).CONCLUSIONS: Our data suggests that age has a statistically significant role on disease free survival and overall survival of dermatofibrosarcoma protuberans patients.

AB - BACKGROUND: Dermatofibrosarcoma protuberans is a malignant tumor that affects exclusively the skin. It is a low- grade malignant tumor of subcutaneous tissues, characterized by a local recurrence but it seldom metastasizes. This study aims to evaluate the impact of different clinical parameters on disease free survival and overall survival of dermatofibrosarcoma protuberans patients.METHODS: A retrospective study of data including 17 cases of dermatofibrosarcoma protuberans (11 male, 6 female) retrieved from the files of the Dermatology Clinics of La Sapienza, University of Rome. We evaluated three clinical parameters (age, sex and anatomic site of the primary tumor) using the Kaplan- Meier product and the log-rank test.RESULTS: The results highlighted that patients with an age ≤ 49 years showed a median disease free survival of 36 months, while patients with an age ≥50 years of 4 months (p < 0.0003). In addition, performing Rank- correlation, only the variable age (p< 0.0001) reached the statistical significance. Regarding overall survival, performing Rank-correlation only the variable age reached the statistical significance (p= 0.02).CONCLUSIONS: Our data suggests that age has a statistically significant role on disease free survival and overall survival of dermatofibrosarcoma protuberans patients.

U2 - 10.23736/S0392-0488.17.05435-9

DO - 10.23736/S0392-0488.17.05435-9

M3 - Article

C2 - 28509521

JO - Giornale Italiano di Dermatologia e Venereologia

JF - Giornale Italiano di Dermatologia e Venereologia

SN - 0392-0488

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