We have analyzed the dermatoglyphic aspects of a patient affected by hypomelanosis of Ito (Incontinentia pigmenti achromians - HI) and of his healthy mother, and have compared our findings with those of the only three other cases in whom such studies had been done. It appeared that hypomelanosis of Ito shows anomalous dermatoglyphic peculiarities: a larger number of ulnar loops and the frequent absence of patterns in thenar, II and III interdigital areas. However, the absence of some interdigital triradii, particularly of d triradius, seems to be the most distinctive character. Since the timing of embryonal life during which d triradius should be formed is between 16 and 17 weeks, it seems highly probable that some developmental abnormality might occur at this point in HI. Moreover, the present analysis allows to support some hypotheses already proposed in the literature, concerning the modalities of determination of the absence of d triradius. The observed concomitance with some dermatoglyphic findings, such as the absence of other palmar triradii and the absence of interdigital patterns, led us to suggest that such characteristics could be connected each other, having perhaps a common genetical basis or undergoing the same microenvironmental effects.
- hypomelanosis of Ito
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