Dermatologic radiotherapy of primary cutaneous follicle center cell lymphoma

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

A retrospective study was performed to evaluate the results of dermatologic radiotherapy in a large series of patients affected by primary cutaneous B-cell lymphomas. The study included 104 patients with cutaneous follicle center cell lymphoma treated with orthovoltage radiotherapy from 1973 to 2000. The total doses ranged from 14 to 35 Gy (mean 23.55 Gy). Results regarded 102 patients (mean follow-up 65.08 months). Complete remission was observed in all cases; 76 patients experienced a relapse after a mean interval of 22.03 months following radiotherapy, with a relapse-free rate of 22.82% after 5 years. Extracutaneous progression was observed in 9 cases (8.82%). An overall actuarial survival rate of 97.36% was observed after 5 years. A salvage treatment of relapses brought 44 cases to remission. Although we have observed a relapse-free rate lower than that reported by others, dermatologic radiotherapy was "curative" in 25.49% of cases. Such treatment appears particularly useful in the cases with few lesions and in the management of new cutaneous localizations of follicular center cell lymphoma.

Original languageEnglish
Pages (from-to)49-52
Number of pages4
JournalEuropean Journal of Dermatology
Volume13
Issue number1
Publication statusPublished - Jan 2003

Fingerprint

Lymphoma
Radiotherapy
Recurrence
Skin
Salvage Therapy
B-Cell Lymphoma
Survival Rate
Retrospective Studies
Therapeutics

Keywords

  • Cutaneous primary B-cell lymphoma
  • Follicular center cell lymphoma
  • Radiotherapy

ASJC Scopus subject areas

  • Dermatology

Cite this

@article{c291585217b14742a2c4985a47589b04,
title = "Dermatologic radiotherapy of primary cutaneous follicle center cell lymphoma",
abstract = "A retrospective study was performed to evaluate the results of dermatologic radiotherapy in a large series of patients affected by primary cutaneous B-cell lymphomas. The study included 104 patients with cutaneous follicle center cell lymphoma treated with orthovoltage radiotherapy from 1973 to 2000. The total doses ranged from 14 to 35 Gy (mean 23.55 Gy). Results regarded 102 patients (mean follow-up 65.08 months). Complete remission was observed in all cases; 76 patients experienced a relapse after a mean interval of 22.03 months following radiotherapy, with a relapse-free rate of 22.82{\%} after 5 years. Extracutaneous progression was observed in 9 cases (8.82{\%}). An overall actuarial survival rate of 97.36{\%} was observed after 5 years. A salvage treatment of relapses brought 44 cases to remission. Although we have observed a relapse-free rate lower than that reported by others, dermatologic radiotherapy was {"}curative{"} in 25.49{\%} of cases. Such treatment appears particularly useful in the cases with few lesions and in the management of new cutaneous localizations of follicular center cell lymphoma.",
keywords = "Cutaneous primary B-cell lymphoma, Follicular center cell lymphoma, Radiotherapy",
author = "Roberta Piccinno and Massimo Caccialanza and Emilio Berti",
year = "2003",
month = "1",
language = "English",
volume = "13",
pages = "49--52",
journal = "European Journal of Dermatology",
issn = "1167-1122",
publisher = "NLM (Medline)",
number = "1",

}

TY - JOUR

T1 - Dermatologic radiotherapy of primary cutaneous follicle center cell lymphoma

AU - Piccinno, Roberta

AU - Caccialanza, Massimo

AU - Berti, Emilio

PY - 2003/1

Y1 - 2003/1

N2 - A retrospective study was performed to evaluate the results of dermatologic radiotherapy in a large series of patients affected by primary cutaneous B-cell lymphomas. The study included 104 patients with cutaneous follicle center cell lymphoma treated with orthovoltage radiotherapy from 1973 to 2000. The total doses ranged from 14 to 35 Gy (mean 23.55 Gy). Results regarded 102 patients (mean follow-up 65.08 months). Complete remission was observed in all cases; 76 patients experienced a relapse after a mean interval of 22.03 months following radiotherapy, with a relapse-free rate of 22.82% after 5 years. Extracutaneous progression was observed in 9 cases (8.82%). An overall actuarial survival rate of 97.36% was observed after 5 years. A salvage treatment of relapses brought 44 cases to remission. Although we have observed a relapse-free rate lower than that reported by others, dermatologic radiotherapy was "curative" in 25.49% of cases. Such treatment appears particularly useful in the cases with few lesions and in the management of new cutaneous localizations of follicular center cell lymphoma.

AB - A retrospective study was performed to evaluate the results of dermatologic radiotherapy in a large series of patients affected by primary cutaneous B-cell lymphomas. The study included 104 patients with cutaneous follicle center cell lymphoma treated with orthovoltage radiotherapy from 1973 to 2000. The total doses ranged from 14 to 35 Gy (mean 23.55 Gy). Results regarded 102 patients (mean follow-up 65.08 months). Complete remission was observed in all cases; 76 patients experienced a relapse after a mean interval of 22.03 months following radiotherapy, with a relapse-free rate of 22.82% after 5 years. Extracutaneous progression was observed in 9 cases (8.82%). An overall actuarial survival rate of 97.36% was observed after 5 years. A salvage treatment of relapses brought 44 cases to remission. Although we have observed a relapse-free rate lower than that reported by others, dermatologic radiotherapy was "curative" in 25.49% of cases. Such treatment appears particularly useful in the cases with few lesions and in the management of new cutaneous localizations of follicular center cell lymphoma.

KW - Cutaneous primary B-cell lymphoma

KW - Follicular center cell lymphoma

KW - Radiotherapy

UR - http://www.scopus.com/inward/record.url?scp=0037280503&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037280503&partnerID=8YFLogxK

M3 - Article

VL - 13

SP - 49

EP - 52

JO - European Journal of Dermatology

JF - European Journal of Dermatology

SN - 1167-1122

IS - 1

ER -