We report a case of Dermatomyofibroma, a recently recognized benign fibrous tissue neoplasm. The lesion occurred in a 24 year-old woman as a red-brown, slowly enlarging plaque localized on the neck. Histologically, Dermatomyofibroma was characterized by a relatively well circumscribed plaque involving the reticular dermis and the upper part of the subcutaneous tissue. The lesion was constituted of a proliferation of uniform spindle-shaped cells arranged in elongated and thin fascicles that tended mostly to interwine haphazardly. Focally, the fascicles showed a parallel arrangement to the skin surface. Thin collagen bundles were seen between the spindle cells that had elongated and wavy nuclei with pointed or rounded ends. Mitotic figures were rarely observed. Adnexal structures were surrounded but not destroyed by the neoplastic proliferation. Immunohistochemical study revealed that the spindle cells stained positively for vimentin and muscle actin whereas they were negative for smooth muscle specific actin, desmin and S-100 protein, suggesting a myofibroblastic differentiation. Histologically, Dermatomyofibroma must be differentiated from other benign and malignant fibrous tissue proliferations such as dermatofibroma, dermatofibrosarcoma protuberans, infantile and myofibromatosis, plexiform fibrohistocytic tumor and superficial and deep fibromatosis.
|Translated title of the contribution||Dermatomyofibroma|
|Number of pages||5|
|Journal||Giornale Italiano di Dermatologia e Venereologia|
|Publication status||Published - 1994|
ASJC Scopus subject areas