Dermatoscopy of basal cell carcinoma: Morphologic variability of global and local features and accuracy of diagnosis

Davide Altamura, Scott W. Menzies, Giuseppe Argenziano, Iris Zalaudek, H. Peter Soyer, Francesco Sera, Michelle Avramidis, Kathryn DeAmbrosis, Maria Concetta Fargnoli, Ketty Peris

Research output: Contribution to journalArticle

192 Citations (Scopus)

Abstract

Background: Early detection of basal cell carcinoma (BCC) is crucial to reduce the morbidity of this tumor. Objective: We sought to investigate the variability and diagnostic significance of dermatoscopic features of BCCs. Methods: We conducted retrospective dermatoscopic analysis of 609 BCCs and 200 melanocytic and nonmelanocytic lesions, and assessment of interrater reliability of dermatoscopic BCC criteria. Results: Lesions included nonpigmented (15.1%), lightly pigmented (33.2%), pigmented (42.7%), and heavily pigmented (9%) BCCs. Classic BCC patterns including arborizing telangiectasia (57.1%), blue/gray ovoid nests (47.5%), ulceration (39.2%), multiple blue/gray globules (26.1%), leaflike areas (15.9%), and spoke-wheel areas (9%) were significantly increased in pigmented BCCs compared with nonpigmented and heavily pigmented BCCs (P = .0001). Among nonclassic BCC patterns, we detected short fine superficial telangiectasia (10%) and multiple small erosions (8.5%), and described two new patterns named "concentric structures" (7.6%) and "multiple in-focus blue/gray dots" (5.1%). Dermatoscopic features suggestive of melanocytic lesions (eg, multiple brown to black dots/globules, blue/white veillike structures, and nonarborizing vessels) were observed in 40.6% BCCs and significantly increased in heavily pigmented BCCs (P <.0001). Expert observers provided an accurate (sensitivity: 97%) and reliable (K: 87%) dermatoscopic diagnosis of BCC, although a significant difference in terms of specificity (P = .0002) and positive predictive value (P = .0004) was found. Arborizing telangiectasia, leaflike areas, and large blue/gray ovoid nests represented reliable and robust diagnostic parameters. Limitation: The study was retrospective. Conclusion: BCCs show a large spectrum of global and local dermatoscopic features; heavily pigmented BCCs show the most challenging combinations of dermatoscopic features.

Original languageEnglish
Pages (from-to)67-75
Number of pages9
JournalJournal of the American Academy of Dermatology
Volume62
Issue number1
DOIs
Publication statusPublished - Jan 2010

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Dermoscopy
Basal Cell Carcinoma
Telangiectasis
Retrospective Studies
Morbidity
Neoplasms

Keywords

  • basal cell carcinoma
  • dermatoscopy
  • early diagnosis of skin tumors

ASJC Scopus subject areas

  • Dermatology

Cite this

Dermatoscopy of basal cell carcinoma : Morphologic variability of global and local features and accuracy of diagnosis. / Altamura, Davide; Menzies, Scott W.; Argenziano, Giuseppe; Zalaudek, Iris; Soyer, H. Peter; Sera, Francesco; Avramidis, Michelle; DeAmbrosis, Kathryn; Fargnoli, Maria Concetta; Peris, Ketty.

In: Journal of the American Academy of Dermatology, Vol. 62, No. 1, 01.2010, p. 67-75.

Research output: Contribution to journalArticle

Altamura, D, Menzies, SW, Argenziano, G, Zalaudek, I, Soyer, HP, Sera, F, Avramidis, M, DeAmbrosis, K, Fargnoli, MC & Peris, K 2010, 'Dermatoscopy of basal cell carcinoma: Morphologic variability of global and local features and accuracy of diagnosis', Journal of the American Academy of Dermatology, vol. 62, no. 1, pp. 67-75. https://doi.org/10.1016/j.jaad.2009.05.035
Altamura, Davide ; Menzies, Scott W. ; Argenziano, Giuseppe ; Zalaudek, Iris ; Soyer, H. Peter ; Sera, Francesco ; Avramidis, Michelle ; DeAmbrosis, Kathryn ; Fargnoli, Maria Concetta ; Peris, Ketty. / Dermatoscopy of basal cell carcinoma : Morphologic variability of global and local features and accuracy of diagnosis. In: Journal of the American Academy of Dermatology. 2010 ; Vol. 62, No. 1. pp. 67-75.
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abstract = "Background: Early detection of basal cell carcinoma (BCC) is crucial to reduce the morbidity of this tumor. Objective: We sought to investigate the variability and diagnostic significance of dermatoscopic features of BCCs. Methods: We conducted retrospective dermatoscopic analysis of 609 BCCs and 200 melanocytic and nonmelanocytic lesions, and assessment of interrater reliability of dermatoscopic BCC criteria. Results: Lesions included nonpigmented (15.1{\%}), lightly pigmented (33.2{\%}), pigmented (42.7{\%}), and heavily pigmented (9{\%}) BCCs. Classic BCC patterns including arborizing telangiectasia (57.1{\%}), blue/gray ovoid nests (47.5{\%}), ulceration (39.2{\%}), multiple blue/gray globules (26.1{\%}), leaflike areas (15.9{\%}), and spoke-wheel areas (9{\%}) were significantly increased in pigmented BCCs compared with nonpigmented and heavily pigmented BCCs (P = .0001). Among nonclassic BCC patterns, we detected short fine superficial telangiectasia (10{\%}) and multiple small erosions (8.5{\%}), and described two new patterns named {"}concentric structures{"} (7.6{\%}) and {"}multiple in-focus blue/gray dots{"} (5.1{\%}). Dermatoscopic features suggestive of melanocytic lesions (eg, multiple brown to black dots/globules, blue/white veillike structures, and nonarborizing vessels) were observed in 40.6{\%} BCCs and significantly increased in heavily pigmented BCCs (P <.0001). Expert observers provided an accurate (sensitivity: 97{\%}) and reliable (K: 87{\%}) dermatoscopic diagnosis of BCC, although a significant difference in terms of specificity (P = .0002) and positive predictive value (P = .0004) was found. Arborizing telangiectasia, leaflike areas, and large blue/gray ovoid nests represented reliable and robust diagnostic parameters. Limitation: The study was retrospective. Conclusion: BCCs show a large spectrum of global and local dermatoscopic features; heavily pigmented BCCs show the most challenging combinations of dermatoscopic features.",
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AU - Argenziano, Giuseppe

AU - Zalaudek, Iris

AU - Soyer, H. Peter

AU - Sera, Francesco

AU - Avramidis, Michelle

AU - DeAmbrosis, Kathryn

AU - Fargnoli, Maria Concetta

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N2 - Background: Early detection of basal cell carcinoma (BCC) is crucial to reduce the morbidity of this tumor. Objective: We sought to investigate the variability and diagnostic significance of dermatoscopic features of BCCs. Methods: We conducted retrospective dermatoscopic analysis of 609 BCCs and 200 melanocytic and nonmelanocytic lesions, and assessment of interrater reliability of dermatoscopic BCC criteria. Results: Lesions included nonpigmented (15.1%), lightly pigmented (33.2%), pigmented (42.7%), and heavily pigmented (9%) BCCs. Classic BCC patterns including arborizing telangiectasia (57.1%), blue/gray ovoid nests (47.5%), ulceration (39.2%), multiple blue/gray globules (26.1%), leaflike areas (15.9%), and spoke-wheel areas (9%) were significantly increased in pigmented BCCs compared with nonpigmented and heavily pigmented BCCs (P = .0001). Among nonclassic BCC patterns, we detected short fine superficial telangiectasia (10%) and multiple small erosions (8.5%), and described two new patterns named "concentric structures" (7.6%) and "multiple in-focus blue/gray dots" (5.1%). Dermatoscopic features suggestive of melanocytic lesions (eg, multiple brown to black dots/globules, blue/white veillike structures, and nonarborizing vessels) were observed in 40.6% BCCs and significantly increased in heavily pigmented BCCs (P <.0001). Expert observers provided an accurate (sensitivity: 97%) and reliable (K: 87%) dermatoscopic diagnosis of BCC, although a significant difference in terms of specificity (P = .0002) and positive predictive value (P = .0004) was found. Arborizing telangiectasia, leaflike areas, and large blue/gray ovoid nests represented reliable and robust diagnostic parameters. Limitation: The study was retrospective. Conclusion: BCCs show a large spectrum of global and local dermatoscopic features; heavily pigmented BCCs show the most challenging combinations of dermatoscopic features.

AB - Background: Early detection of basal cell carcinoma (BCC) is crucial to reduce the morbidity of this tumor. Objective: We sought to investigate the variability and diagnostic significance of dermatoscopic features of BCCs. Methods: We conducted retrospective dermatoscopic analysis of 609 BCCs and 200 melanocytic and nonmelanocytic lesions, and assessment of interrater reliability of dermatoscopic BCC criteria. Results: Lesions included nonpigmented (15.1%), lightly pigmented (33.2%), pigmented (42.7%), and heavily pigmented (9%) BCCs. Classic BCC patterns including arborizing telangiectasia (57.1%), blue/gray ovoid nests (47.5%), ulceration (39.2%), multiple blue/gray globules (26.1%), leaflike areas (15.9%), and spoke-wheel areas (9%) were significantly increased in pigmented BCCs compared with nonpigmented and heavily pigmented BCCs (P = .0001). Among nonclassic BCC patterns, we detected short fine superficial telangiectasia (10%) and multiple small erosions (8.5%), and described two new patterns named "concentric structures" (7.6%) and "multiple in-focus blue/gray dots" (5.1%). Dermatoscopic features suggestive of melanocytic lesions (eg, multiple brown to black dots/globules, blue/white veillike structures, and nonarborizing vessels) were observed in 40.6% BCCs and significantly increased in heavily pigmented BCCs (P <.0001). Expert observers provided an accurate (sensitivity: 97%) and reliable (K: 87%) dermatoscopic diagnosis of BCC, although a significant difference in terms of specificity (P = .0002) and positive predictive value (P = .0004) was found. Arborizing telangiectasia, leaflike areas, and large blue/gray ovoid nests represented reliable and robust diagnostic parameters. Limitation: The study was retrospective. Conclusion: BCCs show a large spectrum of global and local dermatoscopic features; heavily pigmented BCCs show the most challenging combinations of dermatoscopic features.

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