Abstract
BACKGROUND. Dermoscopy is a noninvasive technique that increases the diagnostic accuracy of pigmented skin lesions, particularly improving the diagnosis of patients with cutaneous melanoma in situ (CMIS) and early invasive melanoma. To establish reliable and reproducible dermoscopic criteria for the diagnosis of CMIS, the authors conducted a retrospective clinical study of 37 patients with CMIS and 53 patients with invasive cutaneous melanomas (ICM). METHODS. The 37 patients with CMIS were divided into three groups: Those with CMIS lesions measuring ≤ 5 mm in greatest dimension (8 patients), those with CMIS lesions measuring from > 5 mm to ≤ 10 mm in greatest dimension (20 patients), and those with CMIS lesions measuring > 10 mm in greatest dimension (9 patients). The 53 patients with ICM were divided into two groups according to Breslow index: Those with 1CM lesions measuring ≤ 0.75 mm in tumor thickness (19 patients) and those with ICM lesions measuring > 0.75 mm in tumor thickness (34 patients). Lesions were examined with a dermatoscope and were photographed at a magnification of × 10. Dermoscopic criteria were evaluated from examination of the photomicrographs. RESULTS. Blue-whitish veil, gray-blue areas, black dots, and irregular extensions and branched streaks were the most relevant dermoscopic criteria for CMIS and were present in 78%, 76%, 73%, and 62% of lesions, respectively. Brown globules, irregular pigment network, pseudopods, and depigmentation were present in 57%, 54%, 54%, and 51% of CMIS lesions, respectively. White scar-like areas and linear and/or dotted vascular patterns, two criteria that are associated frequently with ICM, were not found in our patients with CMIS. No clinically significant differences were observed between the three groups of CMIS patients. CONCLUSIONS. Dermoscopic criteria for CMIS were similar to those for 1CM, although white scar-like areas and linear and/or dotted vascular patterns were observed only in patients with 1CM. Dermoscopic criteria appeared to be independent of CMIS lesions size.
| Original language | English |
|---|---|
| Pages (from-to) | 992-997 |
| Number of pages | 6 |
| Journal | Cancer |
| Volume | 91 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Mar 1 2001 |
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Keywords
- Dermoscopy
- Melanocytic skin lesions
- Melanoma in situ, invasive melanoma
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Dermoscopic criteria for melanoma in situ are similar to those for early invasive melanoma. / Pizzichetta, Maria Antonietta; Argenziano, Giuseppe; Talamini, Renato; Piccolo, Domenico; Gatti, Alessandro; Trevisan, Giusto; Sasso, Gian Mauro; Veronesi, Andrea; Carbone, Antonino; Peter Soyer, H.
In: Cancer, Vol. 91, No. 5, 01.03.2001, p. 992-997.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dermoscopic criteria for melanoma in situ are similar to those for early invasive melanoma
AU - Pizzichetta, Maria Antonietta
AU - Argenziano, Giuseppe
AU - Talamini, Renato
AU - Piccolo, Domenico
AU - Gatti, Alessandro
AU - Trevisan, Giusto
AU - Sasso, Gian Mauro
AU - Veronesi, Andrea
AU - Carbone, Antonino
AU - Peter Soyer, H.
PY - 2001/3/1
Y1 - 2001/3/1
N2 - BACKGROUND. Dermoscopy is a noninvasive technique that increases the diagnostic accuracy of pigmented skin lesions, particularly improving the diagnosis of patients with cutaneous melanoma in situ (CMIS) and early invasive melanoma. To establish reliable and reproducible dermoscopic criteria for the diagnosis of CMIS, the authors conducted a retrospective clinical study of 37 patients with CMIS and 53 patients with invasive cutaneous melanomas (ICM). METHODS. The 37 patients with CMIS were divided into three groups: Those with CMIS lesions measuring ≤ 5 mm in greatest dimension (8 patients), those with CMIS lesions measuring from > 5 mm to ≤ 10 mm in greatest dimension (20 patients), and those with CMIS lesions measuring > 10 mm in greatest dimension (9 patients). The 53 patients with ICM were divided into two groups according to Breslow index: Those with 1CM lesions measuring ≤ 0.75 mm in tumor thickness (19 patients) and those with ICM lesions measuring > 0.75 mm in tumor thickness (34 patients). Lesions were examined with a dermatoscope and were photographed at a magnification of × 10. Dermoscopic criteria were evaluated from examination of the photomicrographs. RESULTS. Blue-whitish veil, gray-blue areas, black dots, and irregular extensions and branched streaks were the most relevant dermoscopic criteria for CMIS and were present in 78%, 76%, 73%, and 62% of lesions, respectively. Brown globules, irregular pigment network, pseudopods, and depigmentation were present in 57%, 54%, 54%, and 51% of CMIS lesions, respectively. White scar-like areas and linear and/or dotted vascular patterns, two criteria that are associated frequently with ICM, were not found in our patients with CMIS. No clinically significant differences were observed between the three groups of CMIS patients. CONCLUSIONS. Dermoscopic criteria for CMIS were similar to those for 1CM, although white scar-like areas and linear and/or dotted vascular patterns were observed only in patients with 1CM. Dermoscopic criteria appeared to be independent of CMIS lesions size.
AB - BACKGROUND. Dermoscopy is a noninvasive technique that increases the diagnostic accuracy of pigmented skin lesions, particularly improving the diagnosis of patients with cutaneous melanoma in situ (CMIS) and early invasive melanoma. To establish reliable and reproducible dermoscopic criteria for the diagnosis of CMIS, the authors conducted a retrospective clinical study of 37 patients with CMIS and 53 patients with invasive cutaneous melanomas (ICM). METHODS. The 37 patients with CMIS were divided into three groups: Those with CMIS lesions measuring ≤ 5 mm in greatest dimension (8 patients), those with CMIS lesions measuring from > 5 mm to ≤ 10 mm in greatest dimension (20 patients), and those with CMIS lesions measuring > 10 mm in greatest dimension (9 patients). The 53 patients with ICM were divided into two groups according to Breslow index: Those with 1CM lesions measuring ≤ 0.75 mm in tumor thickness (19 patients) and those with ICM lesions measuring > 0.75 mm in tumor thickness (34 patients). Lesions were examined with a dermatoscope and were photographed at a magnification of × 10. Dermoscopic criteria were evaluated from examination of the photomicrographs. RESULTS. Blue-whitish veil, gray-blue areas, black dots, and irregular extensions and branched streaks were the most relevant dermoscopic criteria for CMIS and were present in 78%, 76%, 73%, and 62% of lesions, respectively. Brown globules, irregular pigment network, pseudopods, and depigmentation were present in 57%, 54%, 54%, and 51% of CMIS lesions, respectively. White scar-like areas and linear and/or dotted vascular patterns, two criteria that are associated frequently with ICM, were not found in our patients with CMIS. No clinically significant differences were observed between the three groups of CMIS patients. CONCLUSIONS. Dermoscopic criteria for CMIS were similar to those for 1CM, although white scar-like areas and linear and/or dotted vascular patterns were observed only in patients with 1CM. Dermoscopic criteria appeared to be independent of CMIS lesions size.
KW - Dermoscopy
KW - Melanocytic skin lesions
KW - Melanoma in situ, invasive melanoma
UR - http://www.scopus.com/inward/record.url?scp=0035281592&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035281592&partnerID=8YFLogxK
U2 - 10.1002/1097-0142(20010301)91:5<992::AID-CNCR1089>3.0.CO;2-I
DO - 10.1002/1097-0142(20010301)91:5<992::AID-CNCR1089>3.0.CO;2-I
M3 - Article
C2 - 11251951
AN - SCOPUS:0035281592
VL - 91
SP - 992
EP - 997
JO - Cancer
JF - Cancer
SN - 0008-543X
IS - 5
ER -