Dermoscopic features and patterns of poromas: A multicentre observational case-control study conducted by the International Dermoscopy Society

M. A. Marchetti, M. L. Marino, P. Virmani, S. W. Dusza, A. A. Marghoob, G. Nazzaro, A. Lallas, C. Landi, H. Cabo, R. Quiñones, E. Gomez, S. Puig, C. Carrera

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Poromas are benign cutaneous sweat gland tumours that are challenging to identify. The dermoscopic features of poromas are not well characterized. Objective: To determine the clinical-dermoscopic features of poromas. Methods: Cross-sectional, observational study of 113 poromas and 106 matched control lesions from 16 contributors and eight countries. Blinded reviewers evaluated the clinical and dermoscopic features present in each clinical and dermoscopic image. Results: Poromas were most commonly non-pigmented (85.8%), papules (35.4%) and located on non-acral sites (65.5%). In multivariate analysis, dermoscopic features associated with poroma included white interlacing areas around vessels (OR: 7.9, 95% CI: 1.9-32.5, P = 0.004), yellow structureless areas (OR: 2.5, 95% CI: 1.1-6.0, P = 0.04), milky-red globules (OR: 3.9, 95% CI: 1.4-11.1, P = 0.01) and poorly visualized vessels (OR: 33.3, 95% CI: 1.9-586.5, P = 0.02). The presence of branched vessels with rounded endings was positively associated with poromas but did not reach statistical significance (OR: 2.4, 95% CI: 0.8-6.5, P = 0.10). The presence of any of these five features was associated with a sensitivity and specificity of 62.8% and 82.0%, respectively. Conclusion: We identified dermoscopic features that are specific to the diagnosis of poroma. Overall, however, the prevalence of these features was low. Significant clinical and dermoscopic variability is a hallmark of these uncommon tumours, which are most prevalent on non-acral sites.

Original languageEnglish
Pages (from-to)1263-1271
JournalJournal of the European Academy of Dermatology and Venereology
Volume32
Issue number8
DOIs
Publication statusPublished - 2018

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Poroma
Dermoscopy
Case-Control Studies
Sweat Glands
Observational Studies
Neoplasms
Multivariate Analysis
Cross-Sectional Studies

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

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Dermoscopic features and patterns of poromas : A multicentre observational case-control study conducted by the International Dermoscopy Society. / Marchetti, M. A.; Marino, M. L.; Virmani, P.; Dusza, S. W.; Marghoob, A. A.; Nazzaro, G.; Lallas, A.; Landi, C.; Cabo, H.; Quiñones, R.; Gomez, E.; Puig, S.; Carrera, C.

In: Journal of the European Academy of Dermatology and Venereology, Vol. 32, No. 8, 2018, p. 1263-1271.

Research output: Contribution to journalArticle

Marchetti, MA, Marino, ML, Virmani, P, Dusza, SW, Marghoob, AA, Nazzaro, G, Lallas, A, Landi, C, Cabo, H, Quiñones, R, Gomez, E, Puig, S & Carrera, C 2018, 'Dermoscopic features and patterns of poromas: A multicentre observational case-control study conducted by the International Dermoscopy Society', Journal of the European Academy of Dermatology and Venereology, vol. 32, no. 8, pp. 1263-1271. https://doi.org/10.1111/jdv.14729
Marchetti, M. A. ; Marino, M. L. ; Virmani, P. ; Dusza, S. W. ; Marghoob, A. A. ; Nazzaro, G. ; Lallas, A. ; Landi, C. ; Cabo, H. ; Quiñones, R. ; Gomez, E. ; Puig, S. ; Carrera, C. / Dermoscopic features and patterns of poromas : A multicentre observational case-control study conducted by the International Dermoscopy Society. In: Journal of the European Academy of Dermatology and Venereology. 2018 ; Vol. 32, No. 8. pp. 1263-1271.
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title = "Dermoscopic features and patterns of poromas: A multicentre observational case-control study conducted by the International Dermoscopy Society",
abstract = "Background: Poromas are benign cutaneous sweat gland tumours that are challenging to identify. The dermoscopic features of poromas are not well characterized. Objective: To determine the clinical-dermoscopic features of poromas. Methods: Cross-sectional, observational study of 113 poromas and 106 matched control lesions from 16 contributors and eight countries. Blinded reviewers evaluated the clinical and dermoscopic features present in each clinical and dermoscopic image. Results: Poromas were most commonly non-pigmented (85.8{\%}), papules (35.4{\%}) and located on non-acral sites (65.5{\%}). In multivariate analysis, dermoscopic features associated with poroma included white interlacing areas around vessels (OR: 7.9, 95{\%} CI: 1.9-32.5, P = 0.004), yellow structureless areas (OR: 2.5, 95{\%} CI: 1.1-6.0, P = 0.04), milky-red globules (OR: 3.9, 95{\%} CI: 1.4-11.1, P = 0.01) and poorly visualized vessels (OR: 33.3, 95{\%} CI: 1.9-586.5, P = 0.02). The presence of branched vessels with rounded endings was positively associated with poromas but did not reach statistical significance (OR: 2.4, 95{\%} CI: 0.8-6.5, P = 0.10). The presence of any of these five features was associated with a sensitivity and specificity of 62.8{\%} and 82.0{\%}, respectively. Conclusion: We identified dermoscopic features that are specific to the diagnosis of poroma. Overall, however, the prevalence of these features was low. Significant clinical and dermoscopic variability is a hallmark of these uncommon tumours, which are most prevalent on non-acral sites.",
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T1 - Dermoscopic features and patterns of poromas

T2 - A multicentre observational case-control study conducted by the International Dermoscopy Society

AU - Marchetti, M. A.

AU - Marino, M. L.

AU - Virmani, P.

AU - Dusza, S. W.

AU - Marghoob, A. A.

AU - Nazzaro, G.

AU - Lallas, A.

AU - Landi, C.

AU - Cabo, H.

AU - Quiñones, R.

AU - Gomez, E.

AU - Puig, S.

AU - Carrera, C.

PY - 2018

Y1 - 2018

N2 - Background: Poromas are benign cutaneous sweat gland tumours that are challenging to identify. The dermoscopic features of poromas are not well characterized. Objective: To determine the clinical-dermoscopic features of poromas. Methods: Cross-sectional, observational study of 113 poromas and 106 matched control lesions from 16 contributors and eight countries. Blinded reviewers evaluated the clinical and dermoscopic features present in each clinical and dermoscopic image. Results: Poromas were most commonly non-pigmented (85.8%), papules (35.4%) and located on non-acral sites (65.5%). In multivariate analysis, dermoscopic features associated with poroma included white interlacing areas around vessels (OR: 7.9, 95% CI: 1.9-32.5, P = 0.004), yellow structureless areas (OR: 2.5, 95% CI: 1.1-6.0, P = 0.04), milky-red globules (OR: 3.9, 95% CI: 1.4-11.1, P = 0.01) and poorly visualized vessels (OR: 33.3, 95% CI: 1.9-586.5, P = 0.02). The presence of branched vessels with rounded endings was positively associated with poromas but did not reach statistical significance (OR: 2.4, 95% CI: 0.8-6.5, P = 0.10). The presence of any of these five features was associated with a sensitivity and specificity of 62.8% and 82.0%, respectively. Conclusion: We identified dermoscopic features that are specific to the diagnosis of poroma. Overall, however, the prevalence of these features was low. Significant clinical and dermoscopic variability is a hallmark of these uncommon tumours, which are most prevalent on non-acral sites.

AB - Background: Poromas are benign cutaneous sweat gland tumours that are challenging to identify. The dermoscopic features of poromas are not well characterized. Objective: To determine the clinical-dermoscopic features of poromas. Methods: Cross-sectional, observational study of 113 poromas and 106 matched control lesions from 16 contributors and eight countries. Blinded reviewers evaluated the clinical and dermoscopic features present in each clinical and dermoscopic image. Results: Poromas were most commonly non-pigmented (85.8%), papules (35.4%) and located on non-acral sites (65.5%). In multivariate analysis, dermoscopic features associated with poroma included white interlacing areas around vessels (OR: 7.9, 95% CI: 1.9-32.5, P = 0.004), yellow structureless areas (OR: 2.5, 95% CI: 1.1-6.0, P = 0.04), milky-red globules (OR: 3.9, 95% CI: 1.4-11.1, P = 0.01) and poorly visualized vessels (OR: 33.3, 95% CI: 1.9-586.5, P = 0.02). The presence of branched vessels with rounded endings was positively associated with poromas but did not reach statistical significance (OR: 2.4, 95% CI: 0.8-6.5, P = 0.10). The presence of any of these five features was associated with a sensitivity and specificity of 62.8% and 82.0%, respectively. Conclusion: We identified dermoscopic features that are specific to the diagnosis of poroma. Overall, however, the prevalence of these features was low. Significant clinical and dermoscopic variability is a hallmark of these uncommon tumours, which are most prevalent on non-acral sites.

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