Dermoscopic features predicting the presence of mitoses in thin melanoma

S Ribero, G Argenziano, A Lallas, E Moscarella, E Benati, M Raucci, S Piana, C Longo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

BACKGROUND: The latest AJCC classification has included the number of mitoses as a factor for upstaging thin melanomas. Meanwhile, while dermoscopy has often been used to predict melanoma thickness, its value in predicting number of mitoses remains unknown.

OBJECTIVE: Our aim is to evaluate the correlation between dermoscopic features and the presence of mitoses in a consecutive cohort of thin melanomas.

METHODS: A case control study has been performed to identify specific dermoscopic parameters that could differentiate thin melanomas with 1 or more mitoses per mm2 from those without mitoses.

RESULTS: Of 177 melanomas equal to or thinner than 1mm, 131 (74%) lesions had no mitoses and 46 (36%) lesions had at least 1 mitosis×mm2. Dermoscopic features associated with the presence of 1 or more mitoses were the following: peripheral streaks (OR 4.11; 95% CI 1.94-8.71) and black colour (OR 4.70; 95% CI; 2.28-9.68). In contrast, atypical pigment network (OR (0.30; 95% CI 0.15-0.61)) and brown colour (OR 0.36; 95% CI 0.18-0.75) were associated to melanomas without mitoses. The same variables were also associated to the increasing number of mitoses at linear regression.

CONCLUSION: Black colour and peripheral streaks can predict the presence of mitoses in thin melanoma, while atypical pigment network and brown colour are associated to thin melanoma without mitoses.

Original languageEnglish
Pages (from-to)158-161
Number of pages4
JournalJournal of Dermatological Science
Volume86
Issue number2
DOIs
Publication statusPublished - May 2017

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Mitosis
Melanoma
Color
Pigments
Linear regression
Dermoscopy
Case-Control Studies
Linear Models

Keywords

  • Adult
  • Aged
  • Case-Control Studies
  • Color
  • Dermoscopy
  • Female
  • Humans
  • Male
  • Melanoma
  • Middle Aged
  • Mitosis
  • Phenotype
  • Pigmentation
  • Retrospective Studies
  • Skin Neoplasms
  • Journal Article

Cite this

Dermoscopic features predicting the presence of mitoses in thin melanoma. / Ribero, S; Argenziano, G; Lallas, A; Moscarella, E; Benati, E; Raucci, M; Piana, S; Longo, C.

In: Journal of Dermatological Science, Vol. 86, No. 2, 05.2017, p. 158-161.

Research output: Contribution to journalArticle

Ribero S, Argenziano G, Lallas A, Moscarella E, Benati E, Raucci M et al. Dermoscopic features predicting the presence of mitoses in thin melanoma. Journal of Dermatological Science. 2017 May;86(2):158-161. https://doi.org/10.1016/j.jdermsci.2017.01.013
Ribero, S ; Argenziano, G ; Lallas, A ; Moscarella, E ; Benati, E ; Raucci, M ; Piana, S ; Longo, C. / Dermoscopic features predicting the presence of mitoses in thin melanoma. In: Journal of Dermatological Science. 2017 ; Vol. 86, No. 2. pp. 158-161.
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abstract = "BACKGROUND: The latest AJCC classification has included the number of mitoses as a factor for upstaging thin melanomas. Meanwhile, while dermoscopy has often been used to predict melanoma thickness, its value in predicting number of mitoses remains unknown.OBJECTIVE: Our aim is to evaluate the correlation between dermoscopic features and the presence of mitoses in a consecutive cohort of thin melanomas.METHODS: A case control study has been performed to identify specific dermoscopic parameters that could differentiate thin melanomas with 1 or more mitoses per mm2 from those without mitoses.RESULTS: Of 177 melanomas equal to or thinner than 1mm, 131 (74{\%}) lesions had no mitoses and 46 (36{\%}) lesions had at least 1 mitosis×mm2. Dermoscopic features associated with the presence of 1 or more mitoses were the following: peripheral streaks (OR 4.11; 95{\%} CI 1.94-8.71) and black colour (OR 4.70; 95{\%} CI; 2.28-9.68). In contrast, atypical pigment network (OR (0.30; 95{\%} CI 0.15-0.61)) and brown colour (OR 0.36; 95{\%} CI 0.18-0.75) were associated to melanomas without mitoses. The same variables were also associated to the increasing number of mitoses at linear regression.CONCLUSION: Black colour and peripheral streaks can predict the presence of mitoses in thin melanoma, while atypical pigment network and brown colour are associated to thin melanoma without mitoses.",
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AU - Ribero, S

AU - Argenziano, G

AU - Lallas, A

AU - Moscarella, E

AU - Benati, E

AU - Raucci, M

AU - Piana, S

AU - Longo, C

N1 - Copyright © 2017 Japanese Society for Investigative Dermatology. All rights reserved.

PY - 2017/5

Y1 - 2017/5

N2 - BACKGROUND: The latest AJCC classification has included the number of mitoses as a factor for upstaging thin melanomas. Meanwhile, while dermoscopy has often been used to predict melanoma thickness, its value in predicting number of mitoses remains unknown.OBJECTIVE: Our aim is to evaluate the correlation between dermoscopic features and the presence of mitoses in a consecutive cohort of thin melanomas.METHODS: A case control study has been performed to identify specific dermoscopic parameters that could differentiate thin melanomas with 1 or more mitoses per mm2 from those without mitoses.RESULTS: Of 177 melanomas equal to or thinner than 1mm, 131 (74%) lesions had no mitoses and 46 (36%) lesions had at least 1 mitosis×mm2. Dermoscopic features associated with the presence of 1 or more mitoses were the following: peripheral streaks (OR 4.11; 95% CI 1.94-8.71) and black colour (OR 4.70; 95% CI; 2.28-9.68). In contrast, atypical pigment network (OR (0.30; 95% CI 0.15-0.61)) and brown colour (OR 0.36; 95% CI 0.18-0.75) were associated to melanomas without mitoses. The same variables were also associated to the increasing number of mitoses at linear regression.CONCLUSION: Black colour and peripheral streaks can predict the presence of mitoses in thin melanoma, while atypical pigment network and brown colour are associated to thin melanoma without mitoses.

AB - BACKGROUND: The latest AJCC classification has included the number of mitoses as a factor for upstaging thin melanomas. Meanwhile, while dermoscopy has often been used to predict melanoma thickness, its value in predicting number of mitoses remains unknown.OBJECTIVE: Our aim is to evaluate the correlation between dermoscopic features and the presence of mitoses in a consecutive cohort of thin melanomas.METHODS: A case control study has been performed to identify specific dermoscopic parameters that could differentiate thin melanomas with 1 or more mitoses per mm2 from those without mitoses.RESULTS: Of 177 melanomas equal to or thinner than 1mm, 131 (74%) lesions had no mitoses and 46 (36%) lesions had at least 1 mitosis×mm2. Dermoscopic features associated with the presence of 1 or more mitoses were the following: peripheral streaks (OR 4.11; 95% CI 1.94-8.71) and black colour (OR 4.70; 95% CI; 2.28-9.68). In contrast, atypical pigment network (OR (0.30; 95% CI 0.15-0.61)) and brown colour (OR 0.36; 95% CI 0.18-0.75) were associated to melanomas without mitoses. The same variables were also associated to the increasing number of mitoses at linear regression.CONCLUSION: Black colour and peripheral streaks can predict the presence of mitoses in thin melanoma, while atypical pigment network and brown colour are associated to thin melanoma without mitoses.

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KW - Case-Control Studies

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KW - Dermoscopy

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KW - Mitosis

KW - Phenotype

KW - Pigmentation

KW - Retrospective Studies

KW - Skin Neoplasms

KW - Journal Article

U2 - 10.1016/j.jdermsci.2017.01.013

DO - 10.1016/j.jdermsci.2017.01.013

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VL - 86

SP - 158

EP - 161

JO - Journal of Dermatological Science

JF - Journal of Dermatological Science

SN - 0923-1811

IS - 2

ER -