Dermoscopy and digital dermoscopy analysis of palmoplantar 'Equivocal' pigmented skin lesions in caucasians

P. Rubegni, G. Cevenini, N. Nami, G. Argenziano, T. Saida, M. Burroni, R. Bono, P. Quaglino, P. Barbini, C. Miracco, A. Lamberti, M. Fimiani

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background/Aim: The diagnosis of palmoplantar melanoma is often delayed and misdiagnosis is common, due to frequently unusual clinical presentation. We used a digital dermoscopy analyzer with a series of palmoplantar pigmented skin lesions (PP-PSL), and we compared sensitivity, specificity and diagnostic accuracy obtained with digital dermoscopy analysis (DDA) and classical dermoscopy. Methods: Digital dermoscopy images of 107 PP-PSL were retrospectively obtained from the database of images of 3 Italian centers. The lesions (25 melanomas and 82 nevi) were all removed because of the presence of clinical and/or dermoscopic suspicious features. All digital images were analyzed using appropriate algorithms, and the diagnostic accuracy of the model was calculated. For comparison, dermoscopic images were clinically evaluated by two dermatologists and the Cohen κ concordance with DDA was calculated. Results: The stepwise logistic regression analysis selected only 5 parameters out of 49. The logistic model achieved a sensitivity of 96% and a specificity of 87.8%. The Cohen κ concordance, evaluated by the Landis and Koch scale, supplied a substantial agreement between dermoscopy and DDA. Conclusions: DDA might be a useful diagnostic instrument in the evaluation of preselected PP-PSL. However, these findings should be confirmed in a formal clinical trial.

Original languageEnglish
Pages (from-to)248-255
Number of pages8
JournalDermatology
Volume225
Issue number3
DOIs
Publication statusPublished - Jan 2013

Fingerprint

Dermoscopy
Skin
Logistic Models
Nevi and Melanomas
Diagnostic Errors
Melanoma
Regression Analysis
Clinical Trials
Databases
Sensitivity and Specificity

Keywords

  • Acral lentiginous melanoma
  • Dermoscopy
  • Digital dermoscopy analysis

ASJC Scopus subject areas

  • Dermatology

Cite this

Rubegni, P., Cevenini, G., Nami, N., Argenziano, G., Saida, T., Burroni, M., ... Fimiani, M. (2013). Dermoscopy and digital dermoscopy analysis of palmoplantar 'Equivocal' pigmented skin lesions in caucasians. Dermatology, 225(3), 248-255. https://doi.org/10.1159/000343928

Dermoscopy and digital dermoscopy analysis of palmoplantar 'Equivocal' pigmented skin lesions in caucasians. / Rubegni, P.; Cevenini, G.; Nami, N.; Argenziano, G.; Saida, T.; Burroni, M.; Bono, R.; Quaglino, P.; Barbini, P.; Miracco, C.; Lamberti, A.; Fimiani, M.

In: Dermatology, Vol. 225, No. 3, 01.2013, p. 248-255.

Research output: Contribution to journalArticle

Rubegni, P, Cevenini, G, Nami, N, Argenziano, G, Saida, T, Burroni, M, Bono, R, Quaglino, P, Barbini, P, Miracco, C, Lamberti, A & Fimiani, M 2013, 'Dermoscopy and digital dermoscopy analysis of palmoplantar 'Equivocal' pigmented skin lesions in caucasians', Dermatology, vol. 225, no. 3, pp. 248-255. https://doi.org/10.1159/000343928
Rubegni, P. ; Cevenini, G. ; Nami, N. ; Argenziano, G. ; Saida, T. ; Burroni, M. ; Bono, R. ; Quaglino, P. ; Barbini, P. ; Miracco, C. ; Lamberti, A. ; Fimiani, M. / Dermoscopy and digital dermoscopy analysis of palmoplantar 'Equivocal' pigmented skin lesions in caucasians. In: Dermatology. 2013 ; Vol. 225, No. 3. pp. 248-255.
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