Dermoscopy features of atypical fibroxanthoma

A multicenter study of the International Dermoscopy Society

Elvira Moscarella, Simonetta Piana, Francesca Specchio, Athanassios Kyrgidis, Gianluca Nazzaro, Maite L Eliceche, Francesco Savoia, Leonardo Bugatti, Giorgio Filosa, Iris Zalaudek, Federica Scarfi, Mike Inskip, Cliff Rosendahl, John H Pyne, Graeme Siggs, Arzu K Toğral, Horatio Cabo, Lubomir Drlik, Aimilios Lallas, Caterina Longo & 1 others Giuseppe Argenziano

Research output: Contribution to journalArticle

Abstract

BACKGROUND/OBJECTIVES: Little is known about the dermoscopic features of atypical fibroxanthoma.

METHODS: This was a case-control study. Atypical fibroxanthoma lesions were compared with a control group with non-melanoma skin cancer.

RESULTS: Altogether 40 atypical fibroxanthoma were collected. Most developed in men (93%), appearing mainly as nodular (63%), amelanotic (93%) and ulcerated (78%) lesions. Most lesions were located on the scalp (55%) and the ears (13%). Dermoscopically, most atypical fibroxanthoma displayed red (83%) and white (70%) structureless areas and irregular linear vessels (43%). A series of features achieved statistical significance when comparing atypical fibroxanthoma with non-melanoma skin cancer. The presence of red and white structureless areas and white lines, and the absence of yellowish-white opaque scales, hairpin vessels and arborising vessels were predictive of atypical fibroxanthoma in univariate analysis. However, when squamous cell carcinoma was excluded from the analysis, none of the criteria achieved statistical significance. When basal cell carcinoma was excluded, three variables achieved statistical significance in predicting atypical fibroxanthoma: red, structureless areas, the absence of opaque yellowish-white scales and absence of white circles.

CONCLUSIONS: Atypical fibroxanthomas seem to be barely distinguishable from basal cell carcinoma dermoscopically, but they are more easily distinguishable from a well to moderately differentiated squamous cell carcinoma. A histopathological examination is needed for the final diagnosis.

Original languageEnglish
Pages (from-to)309-314
Number of pages6
JournalAustralasian Journal of Dermatology
Volume59
Issue number4
DOIs
Publication statusPublished - Nov 2018

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Dermoscopy
Basal Cell Carcinoma
Skin Neoplasms
Multicenter Studies
Squamous Cell Carcinoma
Scalp
Ear
Case-Control Studies
Control Groups

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Dermoscopy features of atypical fibroxanthoma : A multicenter study of the International Dermoscopy Society. / Moscarella, Elvira; Piana, Simonetta; Specchio, Francesca; Kyrgidis, Athanassios; Nazzaro, Gianluca; Eliceche, Maite L; Savoia, Francesco; Bugatti, Leonardo; Filosa, Giorgio; Zalaudek, Iris; Scarfi, Federica; Inskip, Mike; Rosendahl, Cliff; Pyne, John H; Siggs, Graeme; Toğral, Arzu K; Cabo, Horatio; Drlik, Lubomir; Lallas, Aimilios; Longo, Caterina; Argenziano, Giuseppe.

In: Australasian Journal of Dermatology, Vol. 59, No. 4, 11.2018, p. 309-314.

Research output: Contribution to journalArticle

Moscarella, E, Piana, S, Specchio, F, Kyrgidis, A, Nazzaro, G, Eliceche, ML, Savoia, F, Bugatti, L, Filosa, G, Zalaudek, I, Scarfi, F, Inskip, M, Rosendahl, C, Pyne, JH, Siggs, G, Toğral, AK, Cabo, H, Drlik, L, Lallas, A, Longo, C & Argenziano, G 2018, 'Dermoscopy features of atypical fibroxanthoma: A multicenter study of the International Dermoscopy Society', Australasian Journal of Dermatology, vol. 59, no. 4, pp. 309-314. https://doi.org/10.1111/ajd.12802
Moscarella, Elvira ; Piana, Simonetta ; Specchio, Francesca ; Kyrgidis, Athanassios ; Nazzaro, Gianluca ; Eliceche, Maite L ; Savoia, Francesco ; Bugatti, Leonardo ; Filosa, Giorgio ; Zalaudek, Iris ; Scarfi, Federica ; Inskip, Mike ; Rosendahl, Cliff ; Pyne, John H ; Siggs, Graeme ; Toğral, Arzu K ; Cabo, Horatio ; Drlik, Lubomir ; Lallas, Aimilios ; Longo, Caterina ; Argenziano, Giuseppe. / Dermoscopy features of atypical fibroxanthoma : A multicenter study of the International Dermoscopy Society. In: Australasian Journal of Dermatology. 2018 ; Vol. 59, No. 4. pp. 309-314.
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abstract = "BACKGROUND/OBJECTIVES: Little is known about the dermoscopic features of atypical fibroxanthoma.METHODS: This was a case-control study. Atypical fibroxanthoma lesions were compared with a control group with non-melanoma skin cancer.RESULTS: Altogether 40 atypical fibroxanthoma were collected. Most developed in men (93{\%}), appearing mainly as nodular (63{\%}), amelanotic (93{\%}) and ulcerated (78{\%}) lesions. Most lesions were located on the scalp (55{\%}) and the ears (13{\%}). Dermoscopically, most atypical fibroxanthoma displayed red (83{\%}) and white (70{\%}) structureless areas and irregular linear vessels (43{\%}). A series of features achieved statistical significance when comparing atypical fibroxanthoma with non-melanoma skin cancer. The presence of red and white structureless areas and white lines, and the absence of yellowish-white opaque scales, hairpin vessels and arborising vessels were predictive of atypical fibroxanthoma in univariate analysis. However, when squamous cell carcinoma was excluded from the analysis, none of the criteria achieved statistical significance. When basal cell carcinoma was excluded, three variables achieved statistical significance in predicting atypical fibroxanthoma: red, structureless areas, the absence of opaque yellowish-white scales and absence of white circles.CONCLUSIONS: Atypical fibroxanthomas seem to be barely distinguishable from basal cell carcinoma dermoscopically, but they are more easily distinguishable from a well to moderately differentiated squamous cell carcinoma. A histopathological examination is needed for the final diagnosis.",
author = "Elvira Moscarella and Simonetta Piana and Francesca Specchio and Athanassios Kyrgidis and Gianluca Nazzaro and Eliceche, {Maite L} and Francesco Savoia and Leonardo Bugatti and Giorgio Filosa and Iris Zalaudek and Federica Scarfi and Mike Inskip and Cliff Rosendahl and Pyne, {John H} and Graeme Siggs and Toğral, {Arzu K} and Horatio Cabo and Lubomir Drlik and Aimilios Lallas and Caterina Longo and Giuseppe Argenziano",
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T1 - Dermoscopy features of atypical fibroxanthoma

T2 - A multicenter study of the International Dermoscopy Society

AU - Moscarella, Elvira

AU - Piana, Simonetta

AU - Specchio, Francesca

AU - Kyrgidis, Athanassios

AU - Nazzaro, Gianluca

AU - Eliceche, Maite L

AU - Savoia, Francesco

AU - Bugatti, Leonardo

AU - Filosa, Giorgio

AU - Zalaudek, Iris

AU - Scarfi, Federica

AU - Inskip, Mike

AU - Rosendahl, Cliff

AU - Pyne, John H

AU - Siggs, Graeme

AU - Toğral, Arzu K

AU - Cabo, Horatio

AU - Drlik, Lubomir

AU - Lallas, Aimilios

AU - Longo, Caterina

AU - Argenziano, Giuseppe

N1 - © 2018 The Australasian College of Dermatologists.

PY - 2018/11

Y1 - 2018/11

N2 - BACKGROUND/OBJECTIVES: Little is known about the dermoscopic features of atypical fibroxanthoma.METHODS: This was a case-control study. Atypical fibroxanthoma lesions were compared with a control group with non-melanoma skin cancer.RESULTS: Altogether 40 atypical fibroxanthoma were collected. Most developed in men (93%), appearing mainly as nodular (63%), amelanotic (93%) and ulcerated (78%) lesions. Most lesions were located on the scalp (55%) and the ears (13%). Dermoscopically, most atypical fibroxanthoma displayed red (83%) and white (70%) structureless areas and irregular linear vessels (43%). A series of features achieved statistical significance when comparing atypical fibroxanthoma with non-melanoma skin cancer. The presence of red and white structureless areas and white lines, and the absence of yellowish-white opaque scales, hairpin vessels and arborising vessels were predictive of atypical fibroxanthoma in univariate analysis. However, when squamous cell carcinoma was excluded from the analysis, none of the criteria achieved statistical significance. When basal cell carcinoma was excluded, three variables achieved statistical significance in predicting atypical fibroxanthoma: red, structureless areas, the absence of opaque yellowish-white scales and absence of white circles.CONCLUSIONS: Atypical fibroxanthomas seem to be barely distinguishable from basal cell carcinoma dermoscopically, but they are more easily distinguishable from a well to moderately differentiated squamous cell carcinoma. A histopathological examination is needed for the final diagnosis.

AB - BACKGROUND/OBJECTIVES: Little is known about the dermoscopic features of atypical fibroxanthoma.METHODS: This was a case-control study. Atypical fibroxanthoma lesions were compared with a control group with non-melanoma skin cancer.RESULTS: Altogether 40 atypical fibroxanthoma were collected. Most developed in men (93%), appearing mainly as nodular (63%), amelanotic (93%) and ulcerated (78%) lesions. Most lesions were located on the scalp (55%) and the ears (13%). Dermoscopically, most atypical fibroxanthoma displayed red (83%) and white (70%) structureless areas and irregular linear vessels (43%). A series of features achieved statistical significance when comparing atypical fibroxanthoma with non-melanoma skin cancer. The presence of red and white structureless areas and white lines, and the absence of yellowish-white opaque scales, hairpin vessels and arborising vessels were predictive of atypical fibroxanthoma in univariate analysis. However, when squamous cell carcinoma was excluded from the analysis, none of the criteria achieved statistical significance. When basal cell carcinoma was excluded, three variables achieved statistical significance in predicting atypical fibroxanthoma: red, structureless areas, the absence of opaque yellowish-white scales and absence of white circles.CONCLUSIONS: Atypical fibroxanthomas seem to be barely distinguishable from basal cell carcinoma dermoscopically, but they are more easily distinguishable from a well to moderately differentiated squamous cell carcinoma. A histopathological examination is needed for the final diagnosis.

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DO - 10.1111/ajd.12802

M3 - Article

VL - 59

SP - 309

EP - 314

JO - Australasian Journal of Dermatology

JF - Australasian Journal of Dermatology

SN - 0004-8380

IS - 4

ER -