Dermoscopy of pigmented lesions of the mucosa and the mucocutaneous junction: Results of a multicenter study by the International Dermoscopy Society (IDS)

Andreas Blum, Olga Simionescu, Giuseppe Argenziano, Ralph Braun, Horacio Cabo, Astrid Eichhorn, Herbert Kirchesch, Josep Malvehy, Ashfaq A. Marghoob, Susana Puig, Fezal Özdemir, Wilhelm Stolz, Isabelle Tromme, Ulrike Weigert, Ingrid H. Wolf, Iris Zalaudek, Harald Kittler

Research output: Contribution to journalArticle

Abstract

Objective: To better characterize the dermoscopic patterns of mucosal lesions in relation to the histopathologic characteristics. Design: Retrospective and observational study. Setting: Fourteen referral pigmented lesion clinics in 10 countries. Patients: A total of 140 pigmented mucosal lesions (126 benign lesions, 11 melanomas, 2 Bowen disease lesions, and 1 metastasis) from 92 females (66%) and 48 males (34%) were collected from October 2007 through November 2008. Main Outcome Measures: Scoring the dermoscopic patterns (dots, globules, or clods, circles, lines, or structureless) andcolors (brown, black, blue, gray, red, purple,andwhite) and correlation with the histopathologic characteristics. Results: Based on univariate analysis and 2 diagnostic models, the presence of structureless zones inside the lesions with blue, gray, or white color (the first model) had a 100% sensitivity for melanoma and 92.9% sensitivity for any malignant lesion, and 82.2% and 83.3% specificity for benign lesions in the group with melanoma lesions and the group with malignant lesions, respectively. Based on the colors (blue, gray, or white) only (the second model), the sensitivity for the group with melanoma was 100% and for the group with any malignant lesionwas 92.9%, and the specificity was 64.3% and 65.1%, respectively. Patients with malignant lesions were significantly older than patients with benign lesions (mean [SD] ages, 60.1 [22.8] years vs 43.2 [17.3] years, respectively). Conclusion: The combination of blue, gray, or white color with structureless zones are the strongest indicators when differentiating between benign and malignant mucosal lesions in dermoscopy.

Original languageEnglish
Pages (from-to)1181-1187
Number of pages7
JournalArchives of Dermatology
Volume147
Issue number10
DOIs
Publication statusPublished - Oct 2011

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Dermoscopy
Multicenter Studies
Melanoma
Mucous Membrane
Color
Bowen's Disease
Observational Studies
Referral and Consultation
Retrospective Studies
Outcome Assessment (Health Care)
Neoplasm Metastasis

ASJC Scopus subject areas

  • Dermatology

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Dermoscopy of pigmented lesions of the mucosa and the mucocutaneous junction : Results of a multicenter study by the International Dermoscopy Society (IDS). / Blum, Andreas; Simionescu, Olga; Argenziano, Giuseppe; Braun, Ralph; Cabo, Horacio; Eichhorn, Astrid; Kirchesch, Herbert; Malvehy, Josep; Marghoob, Ashfaq A.; Puig, Susana; Özdemir, Fezal; Stolz, Wilhelm; Tromme, Isabelle; Weigert, Ulrike; Wolf, Ingrid H.; Zalaudek, Iris; Kittler, Harald.

In: Archives of Dermatology, Vol. 147, No. 10, 10.2011, p. 1181-1187.

Research output: Contribution to journalArticle

Blum, A, Simionescu, O, Argenziano, G, Braun, R, Cabo, H, Eichhorn, A, Kirchesch, H, Malvehy, J, Marghoob, AA, Puig, S, Özdemir, F, Stolz, W, Tromme, I, Weigert, U, Wolf, IH, Zalaudek, I & Kittler, H 2011, 'Dermoscopy of pigmented lesions of the mucosa and the mucocutaneous junction: Results of a multicenter study by the International Dermoscopy Society (IDS)', Archives of Dermatology, vol. 147, no. 10, pp. 1181-1187. https://doi.org/10.1001/archdermatol.2011.155
Blum, Andreas ; Simionescu, Olga ; Argenziano, Giuseppe ; Braun, Ralph ; Cabo, Horacio ; Eichhorn, Astrid ; Kirchesch, Herbert ; Malvehy, Josep ; Marghoob, Ashfaq A. ; Puig, Susana ; Özdemir, Fezal ; Stolz, Wilhelm ; Tromme, Isabelle ; Weigert, Ulrike ; Wolf, Ingrid H. ; Zalaudek, Iris ; Kittler, Harald. / Dermoscopy of pigmented lesions of the mucosa and the mucocutaneous junction : Results of a multicenter study by the International Dermoscopy Society (IDS). In: Archives of Dermatology. 2011 ; Vol. 147, No. 10. pp. 1181-1187.
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abstract = "Objective: To better characterize the dermoscopic patterns of mucosal lesions in relation to the histopathologic characteristics. Design: Retrospective and observational study. Setting: Fourteen referral pigmented lesion clinics in 10 countries. Patients: A total of 140 pigmented mucosal lesions (126 benign lesions, 11 melanomas, 2 Bowen disease lesions, and 1 metastasis) from 92 females (66{\%}) and 48 males (34{\%}) were collected from October 2007 through November 2008. Main Outcome Measures: Scoring the dermoscopic patterns (dots, globules, or clods, circles, lines, or structureless) andcolors (brown, black, blue, gray, red, purple,andwhite) and correlation with the histopathologic characteristics. Results: Based on univariate analysis and 2 diagnostic models, the presence of structureless zones inside the lesions with blue, gray, or white color (the first model) had a 100{\%} sensitivity for melanoma and 92.9{\%} sensitivity for any malignant lesion, and 82.2{\%} and 83.3{\%} specificity for benign lesions in the group with melanoma lesions and the group with malignant lesions, respectively. Based on the colors (blue, gray, or white) only (the second model), the sensitivity for the group with melanoma was 100{\%} and for the group with any malignant lesionwas 92.9{\%}, and the specificity was 64.3{\%} and 65.1{\%}, respectively. Patients with malignant lesions were significantly older than patients with benign lesions (mean [SD] ages, 60.1 [22.8] years vs 43.2 [17.3] years, respectively). Conclusion: The combination of blue, gray, or white color with structureless zones are the strongest indicators when differentiating between benign and malignant mucosal lesions in dermoscopy.",
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T1 - Dermoscopy of pigmented lesions of the mucosa and the mucocutaneous junction

T2 - Results of a multicenter study by the International Dermoscopy Society (IDS)

AU - Blum, Andreas

AU - Simionescu, Olga

AU - Argenziano, Giuseppe

AU - Braun, Ralph

AU - Cabo, Horacio

AU - Eichhorn, Astrid

AU - Kirchesch, Herbert

AU - Malvehy, Josep

AU - Marghoob, Ashfaq A.

AU - Puig, Susana

AU - Özdemir, Fezal

AU - Stolz, Wilhelm

AU - Tromme, Isabelle

AU - Weigert, Ulrike

AU - Wolf, Ingrid H.

AU - Zalaudek, Iris

AU - Kittler, Harald

PY - 2011/10

Y1 - 2011/10

N2 - Objective: To better characterize the dermoscopic patterns of mucosal lesions in relation to the histopathologic characteristics. Design: Retrospective and observational study. Setting: Fourteen referral pigmented lesion clinics in 10 countries. Patients: A total of 140 pigmented mucosal lesions (126 benign lesions, 11 melanomas, 2 Bowen disease lesions, and 1 metastasis) from 92 females (66%) and 48 males (34%) were collected from October 2007 through November 2008. Main Outcome Measures: Scoring the dermoscopic patterns (dots, globules, or clods, circles, lines, or structureless) andcolors (brown, black, blue, gray, red, purple,andwhite) and correlation with the histopathologic characteristics. Results: Based on univariate analysis and 2 diagnostic models, the presence of structureless zones inside the lesions with blue, gray, or white color (the first model) had a 100% sensitivity for melanoma and 92.9% sensitivity for any malignant lesion, and 82.2% and 83.3% specificity for benign lesions in the group with melanoma lesions and the group with malignant lesions, respectively. Based on the colors (blue, gray, or white) only (the second model), the sensitivity for the group with melanoma was 100% and for the group with any malignant lesionwas 92.9%, and the specificity was 64.3% and 65.1%, respectively. Patients with malignant lesions were significantly older than patients with benign lesions (mean [SD] ages, 60.1 [22.8] years vs 43.2 [17.3] years, respectively). Conclusion: The combination of blue, gray, or white color with structureless zones are the strongest indicators when differentiating between benign and malignant mucosal lesions in dermoscopy.

AB - Objective: To better characterize the dermoscopic patterns of mucosal lesions in relation to the histopathologic characteristics. Design: Retrospective and observational study. Setting: Fourteen referral pigmented lesion clinics in 10 countries. Patients: A total of 140 pigmented mucosal lesions (126 benign lesions, 11 melanomas, 2 Bowen disease lesions, and 1 metastasis) from 92 females (66%) and 48 males (34%) were collected from October 2007 through November 2008. Main Outcome Measures: Scoring the dermoscopic patterns (dots, globules, or clods, circles, lines, or structureless) andcolors (brown, black, blue, gray, red, purple,andwhite) and correlation with the histopathologic characteristics. Results: Based on univariate analysis and 2 diagnostic models, the presence of structureless zones inside the lesions with blue, gray, or white color (the first model) had a 100% sensitivity for melanoma and 92.9% sensitivity for any malignant lesion, and 82.2% and 83.3% specificity for benign lesions in the group with melanoma lesions and the group with malignant lesions, respectively. Based on the colors (blue, gray, or white) only (the second model), the sensitivity for the group with melanoma was 100% and for the group with any malignant lesionwas 92.9%, and the specificity was 64.3% and 65.1%, respectively. Patients with malignant lesions were significantly older than patients with benign lesions (mean [SD] ages, 60.1 [22.8] years vs 43.2 [17.3] years, respectively). Conclusion: The combination of blue, gray, or white color with structureless zones are the strongest indicators when differentiating between benign and malignant mucosal lesions in dermoscopy.

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