Dermoscopy of solitary angiokeratomas: A morphological study

Pedro Zaballos, Cinta Daufí, Susana Puig, Giuseppe Argenziano, David Moreno-Ramírez, Horacio Cabo, Ashfaq A. Marghoob, Álex Llambrich, Iris Zalaudek, Josep Malvehy

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Objectives: To describe the dermoscopic structures and patterns associated with solitary angiokeratomas and to determine the sensitivity, specificity, positive predictive value, negative predictive value, and reproducibility of these dermoscopic features. Design: Multicenter retrospective study. Setting: University hospitals in Spain, Italy, Argentina, New York City, and Austria. Patients: There were 256 patients total, and 32 specimens each of solitary angiokeratomas, melanocytic nevi, Spitz-Reed nevi, malignant melanomas, pigmented basal cell carcinomas, dermatofibromas, seborrheic keratoses, and other vascular lesions (19 angiomas, 7 pyogenic granulomas, 3 spider nevi, 2 lymphangiomas, and 1 venous lake) were consecutively collected from the laboratories of 8 hospitals. Diagnoses of all patients' lesions were confirmed histopathologically. Intervention: Dermoscopic examination. Main Outcome Measures: The frequency, sensitivity, specificity, positive predictive value, negative predictive value, intraobserver agreement, and interobserver agreement of the different dermoscopic features associated with solitary angiokeratomas were calculated, and the differences were evaluated using the χ2 or Fisher exact test. Results: Six dermoscopic structures were evident in at least 50% of the solitary angiokeratomas: dark lacunae (94%), whitish veil (91%), erythema (69%), peripheral erythema (53%), red lacunae (53%), and hemorrhagic crusts (53%). Dark lacunae exhibited a sensitivity of 93.8% and a specificity of 99.1% (P

Original languageEnglish
Pages (from-to)318-325
Number of pages8
JournalArchives of Dermatology
Issue number3
Publication statusPublished - Mar 2007

ASJC Scopus subject areas

  • Dermatology

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    Zaballos, P., Daufí, C., Puig, S., Argenziano, G., Moreno-Ramírez, D., Cabo, H., Marghoob, A. A., Llambrich, Á., Zalaudek, I., & Malvehy, J. (2007). Dermoscopy of solitary angiokeratomas: A morphological study. Archives of Dermatology, 143(3), 318-325.