Description of a new HLA-DRB1 allele, DRB1*1139

E. Longhi, S. Frison, F. Poli, M. Scalamogna, G. Sirchia

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We report the identification of a novel DRB1*11 using sequence-based typing. This new allele, officially named DRB1*1139, was detected while performing HLA-DRB1 high-resolution typing of a volunteer bone marrow donor. DRB1*1139 is identical to DRB1*11011 except at codon 51 (ACG→AGG) changing the encoded Threonine to Arginine. The triplet AGG has never been found in any other DRB1 allele. In fact, with standard polymerase chain reaction (PCR) amplification with sequence specific primers, the presented allele would have been interpreted as DRB1*1101.

Original languageEnglish
Pages (from-to)388-389
Number of pages2
JournalTissue Antigens
Volume57
Issue number4
DOIs
Publication statusPublished - 2001

Fingerprint

HLA-DRB1 Chains
Polymerase chain reaction
Threonine
Amplification
Arginine
Bone
Alleles
Codon
Volunteers
Bone Marrow
Tissue Donors
Polymerase Chain Reaction

Keywords

  • DNA direct sequencing
  • HLA-DRB*11

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

Cite this

Description of a new HLA-DRB1 allele, DRB1*1139. / Longhi, E.; Frison, S.; Poli, F.; Scalamogna, M.; Sirchia, G.

In: Tissue Antigens, Vol. 57, No. 4, 2001, p. 388-389.

Research output: Contribution to journalArticle

Longhi, E. ; Frison, S. ; Poli, F. ; Scalamogna, M. ; Sirchia, G. / Description of a new HLA-DRB1 allele, DRB1*1139. In: Tissue Antigens. 2001 ; Vol. 57, No. 4. pp. 388-389.
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