Description of HLA-A*0127N, a novel nonexpressed allele identified by SBT

Elena Longhi, Sara Frison, Emanuela Andreini, Katerina Karpasitou, Marta Serafini, Francesca Poli

Research output: Contribution to journalArticle

Abstract

We describe the isolation and characterization of a novel HLA-A null allele, officially named A*0127N. The A*0127N exon 2, 3, and 4 nucleotide sequence is identical to that of A*010101 except at position 553, where a G is substituted by a T, resulting in a coding change in exon 3 (GAG>TAG) from Glu to the stop codon AMB. The mutation described is responsible for the premature ending of the translation.

Original languageEnglish
Pages (from-to)913-914
Number of pages2
JournalHuman Immunology
Volume68
Issue number11
DOIs
Publication statusPublished - Nov 2007

Keywords

  • HLA-A*0127N
  • Nonexpressed alleles
  • SBT

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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