Description of the L76V Resistance Protease Mutation in HIV-1 B and "Non-B" Subtypes

Charlotte Charpentier, Sidonie Lambert-Niclot, Claudia Alteri, Alexandre Storto, Philippe Flandre, Valentina Svicher, Carlo Federico Perno, Françoise Brun-Vézinet, Vincent Calvez, Anne Geneviève Marcelin, Francesca Ceccherini-Silberstein, Diane Descamps

Research output: Contribution to journalArticle

Abstract

Objective: To describe the prevalence of the L76V protease inhibitors resistance-associated mutation (PI-RAM) in relation with patients' characteristics and protease genotypic background in HIV-1 B- and "non-B"-infected patients. Methods: Frequency of the L76V mutation between 1998 and 2010 was surveyed in the laboratory database of 3 clinical centers. Major PI-RAMs were identified according to the IAS-USA list. Fisher's and Wilcoxon tests were used to compare variables. Results: Among the overall 29,643 sequences analyzed, the prevalence of L76V was 1.50%, while was 5.42% in PI-resistant viruses. Since 2008 the prevalence of L76V was higher in "non-B"-infected than in B-infected patients each year. Median time since diagnosis of HIV-1 infection and median time under antiretroviral-based regimen were both shorter in "non-B"- than in B-infected patients (8 vs 11 years, P

Original languageEnglish
Article numbere54381
JournalPLoS One
Volume8
Issue number1
DOIs
Publication statusPublished - Jan 18 2013

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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    Charpentier, C., Lambert-Niclot, S., Alteri, C., Storto, A., Flandre, P., Svicher, V., Perno, C. F., Brun-Vézinet, F., Calvez, V., Marcelin, A. G., Ceccherini-Silberstein, F., & Descamps, D. (2013). Description of the L76V Resistance Protease Mutation in HIV-1 B and "Non-B" Subtypes. PLoS One, 8(1), [e54381]. https://doi.org/10.1371/journal.pone.0054381