Descriptive epidemiology of ovarian cancer in Europe

Carlo La Vecchia, Fabio Levi, Franca Lucchini, Eva Negri, Silvia Franceschi

Research output: Contribution to journalArticlepeer-review

Abstract

Trends in ovarian cancer mortality over the period 1955-1989 were analyzed for 25 European countries (excluding the Soviet Union and a few small countries) on the basis of the official death certification data from the World Health Organization database. The overall variation in age-standardized ovarian cancer mortality at all ages declined appreciably, from over 17-fold during the period 1955-1959 (i.e., between 10.5 100,000 in Denmark and 0.6 100,000 in Spain, world standard) to 3.4-fold (i.e., between 9.9 100,000 in Denmark and 2.9 100,000 in Spain) in the late 1980s. When a comparison was made between the late 1950s and the 1980s, ovarian cancer mortality increased in most European countries, except Denmark, Sweden, and Switzerland, where certified mortality was already elevated in the late 1950s, although also in these countries the peak rate around or over 10 100,000 was reached during the 1960s. However, when the changes over the last decade were considered, ovarian cancer mortality trends were downward in all Nordic countries, Germany, Switzerland, Austria, and Czechoslovakia. Mortality was rising somewhat, though to a smaller extent, in Ireland, Britain, and Southern Europe. Trends were more favorable in middle-aged women (35 to 64 years), and, to an even greater extent, in young women (aged 20 to 44), among whom substantial declines, particularly over the last decade, were observed in most European countries, approaching 50% in Britain and Scandinavia. These trends are discussed in terms of changes in risk factor exposure (i.e., trends in average parity and oral contraceptive use), diagnostic and therapeutic improvements, ovariectomy, and changes in case ascertainment and certification.

Original languageEnglish
Pages (from-to)208-215
Number of pages8
JournalGynecologic Oncology
Volume46
Issue number2
DOIs
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

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