Design and synthesis of novel isoxazole-based HDAC inhibitors

Paola Conti, Lucia Tamborini, Andrea Pinto, Laura Sola, Roberta Ettari, Ciro Mercurio, Carlo De Micheli

Research output: Contribution to journalArticlepeer-review

Abstract

A series of isoxazole-based histone deacetylase (HDAC) inhibitors structurally related to SAHA were designed and synthesized. The isoxazole moiety was inserted in the vicinity of the Zn2+-binding group in order to check its participation in the coordinating process. New isoxazole-based histone deacetylase inhibitors structurally related to SAHA were designed and synthesized to check the participation of the isoxazole moiety in the Zn 2+coordination.

Original languageEnglish
Pages (from-to)4331-4338
Number of pages8
JournalEuropean Journal of Medicinal Chemistry
Volume45
Issue number9
DOIs
Publication statusPublished - Sep 2010

Keywords

  • 1,3-Dipolar cycloaddition
  • Enzyme inhibition
  • Histone deacetylase
  • Isoxazole
  • Zinc binding group

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

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