Design and synthesis of novel isoxazole-based HDAC inhibitors

Paola Conti, Lucia Tamborini, Andrea Pinto, Laura Sola, Roberta Ettari, Ciro Mercurio, Carlo De Micheli

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

A series of isoxazole-based histone deacetylase (HDAC) inhibitors structurally related to SAHA were designed and synthesized. The isoxazole moiety was inserted in the vicinity of the Zn2+-binding group in order to check its participation in the coordinating process. New isoxazole-based histone deacetylase inhibitors structurally related to SAHA were designed and synthesized to check the participation of the isoxazole moiety in the Zn 2+coordination.

Original languageEnglish
Pages (from-to)4331-4338
Number of pages8
JournalEuropean Journal of Medicinal Chemistry
Volume45
Issue number9
DOIs
Publication statusPublished - Sep 2010

Fingerprint

Isoxazoles
Histone Deacetylase Inhibitors

Keywords

  • 1,3-Dipolar cycloaddition
  • Enzyme inhibition
  • Histone deacetylase
  • Isoxazole
  • Zinc binding group

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Conti, P., Tamborini, L., Pinto, A., Sola, L., Ettari, R., Mercurio, C., & De Micheli, C. (2010). Design and synthesis of novel isoxazole-based HDAC inhibitors. European Journal of Medicinal Chemistry, 45(9), 4331-4338. https://doi.org/10.1016/j.ejmech.2010.06.035

Design and synthesis of novel isoxazole-based HDAC inhibitors. / Conti, Paola; Tamborini, Lucia; Pinto, Andrea; Sola, Laura; Ettari, Roberta; Mercurio, Ciro; De Micheli, Carlo.

In: European Journal of Medicinal Chemistry, Vol. 45, No. 9, 09.2010, p. 4331-4338.

Research output: Contribution to journalArticle

Conti, P, Tamborini, L, Pinto, A, Sola, L, Ettari, R, Mercurio, C & De Micheli, C 2010, 'Design and synthesis of novel isoxazole-based HDAC inhibitors', European Journal of Medicinal Chemistry, vol. 45, no. 9, pp. 4331-4338. https://doi.org/10.1016/j.ejmech.2010.06.035
Conti P, Tamborini L, Pinto A, Sola L, Ettari R, Mercurio C et al. Design and synthesis of novel isoxazole-based HDAC inhibitors. European Journal of Medicinal Chemistry. 2010 Sep;45(9):4331-4338. https://doi.org/10.1016/j.ejmech.2010.06.035
Conti, Paola ; Tamborini, Lucia ; Pinto, Andrea ; Sola, Laura ; Ettari, Roberta ; Mercurio, Ciro ; De Micheli, Carlo. / Design and synthesis of novel isoxazole-based HDAC inhibitors. In: European Journal of Medicinal Chemistry. 2010 ; Vol. 45, No. 9. pp. 4331-4338.
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