Design, development and characterization of multi-functionalized gold nanoparticles for biodetection and targeted boron delivery in BNCT applications

Subhra Mandal, Gerald J. Bakeine, Silke Krol, Cinzia Ferrari, Anna M. Clerici, Cecilia Zonta, Laura Cansolino, Francesca Ballarini, Silva Bortolussi, Subrina Stella, Nicoletta Protti, Piero Bruschi, Saverio Altieri

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study is to optimize targeted boron delivery to cancer cells and its tracking down to the cellular level. To this end, we describe the design and synthesis of novel nanovectors that double as targeted boron delivery agents and fluorescent imaging probes. Gold nanoparticles were coated with multilayers of polyelectrolytes functionalized with the fluorescent dye (FITC), boronophenylalanine and folic acid. In vitro confocal fluorescence microscopy demonstrated significant uptake of the nanoparticles in cancer cells that are known to overexpress folate receptors.

Original languageEnglish
Pages (from-to)1692-1697
Number of pages6
JournalApplied Radiation and Isotopes
Volume69
Issue number12
DOIs
Publication statusPublished - Dec 2011

Keywords

  • Biocompatibility
  • BNCT
  • Folate receptor
  • Functionalized gold nanoparticles
  • Optical molecular imaging
  • Targeted boron delivery

ASJC Scopus subject areas

  • Radiation

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