Design of a multimodal fibers optic system for small animal optical imaging

Antonello E. Spinelli, Marco Pagliazzi, Federico Boschi

Research output: Contribution to journalArticlepeer-review

Abstract

Small animals optical imaging systems are widely used in pre-clinical research to image invivo the bio-distribution of light emitting probes using fluorescence or bioluminescence modalities. In this work we presented a set of simulated results of a novel small animal optical imaging module based on a fibers optics matrix, coupled with a position sensitive detector, devoted to acquire bioluminescence and Cerenkov images. Simulations were performed using GEANT 4 code with the GAMOS architecture using the tissue optics plugin. Results showed that it is possible to image a 30×30mm region of interest using a fiber optics array containing 100 optical fibers without compromising the quality of the reconstruction. The number of fibers necessary to cover an adequate portion of a small animal is thus quite modest. This design allows integrating the module with magnetic resonance (MR) in order to acquire optical and MR images at the same time. A detailed model of the mouse anatomy, obtained by segmentation of 3D MRI images, will improve the quality of optical 3D reconstruction.

Original languageEnglish
Pages (from-to)108-111
Number of pages4
JournalPhysica Medica
Volume31
Issue number1
DOIs
Publication statusPublished - 2015

Keywords

  • Magnetic resonance
  • Optics
  • Photonics
  • Small animal imaging

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Physics and Astronomy(all)
  • Medicine(all)

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