Design of a novel procedure for the optimization of the mechanical performances of 3D printed scaffolds for bone tissue engineering combining CAD, Taguchi method and FEA

Gregorio Marchiori, Matteo Berni, Marco Boi, Mauro Petretta, Brunella Grigolo, Devis Bellucci, Valeria Cannillo, Chiara Garavelli, Michele Bianchi

Research output: Contribution to journalArticle

Abstract

In order to increase manufacturing and experimental efficiency, a certain degree of control over design performances before realization phase is recommended. In this context, this paper presents an integrated procedure to design 3D scaffolds for bone tissue engineering. The procedure required a combination of Computer Aided Design (CAD), Finite Element Analysis (FEA), and Design methodologies Of Experiments (DOE), firstly to understand the influence of the design parameters, and then to control them. Based on inputs from the literature and limitations imposed by the chosen manufacturing process (Precision Extrusion Deposition), 36 scaffold architectures have been drawn. The porosity of each scaffold has been calculated with CAD. Thereafter, a generic scaffold material was considered and its variable parameters were combined with the geometrical ones according to the Taguchi method, i.e. a DOE method. The compressive response of those principal combinations was simulated by FEA, and the influence of each design parameter on the scaffold compressive behaviour was clarified. Finally, a regression model was obtained correlating the scaffold's mechanical performances to its geometrical and material parameters. This model has been applied to a novel composite material made of polycaprolactone and innovative bioactive glass. By setting specific porosity (50%) and stiffness (0.05 GPa) suitable for trabecular bone substitutes, the model selected 4 of the 36 initial scaffold architectures. Only these 4 more promising geometries will be realized and physically tested for advanced indications on compressive strength and biocompatibility.

Original languageEnglish
JournalMedical Engineering and Physics
DOIs
Publication statusE-pub ahead of print - May 14 2019

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Computer-Aided Design
Finite Element Analysis
Taguchi methods
Tissue Engineering
Scaffolds (biology)
Tissue engineering
Scaffolds
Computer aided design
Bone
Finite element method
Bone and Bones
Porosity
Compressive Strength
Bone Substitutes
Glass
Bioactive glass
Polycaprolactone
Efficiency
Biocompatibility
Design of experiments

Keywords

  • 3D printing
  • Compressive modulus
  • Design of experiments
  • Scaffold

Cite this

Design of a novel procedure for the optimization of the mechanical performances of 3D printed scaffolds for bone tissue engineering combining CAD, Taguchi method and FEA. / Marchiori, Gregorio; Berni, Matteo; Boi, Marco; Petretta, Mauro; Grigolo, Brunella; Bellucci, Devis; Cannillo, Valeria; Garavelli, Chiara; Bianchi, Michele.

In: Medical Engineering and Physics, 14.05.2019.

Research output: Contribution to journalArticle

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AU - Grigolo, Brunella

AU - Bellucci, Devis

AU - Cannillo, Valeria

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