Design of novel three-phase PCL/TZ-HA biomaterials for use in bone regeneration applications

Aurelio Salerno, Maria Oliviero, Ernesto Di Maio, Paolo A. Netti, Cristina Rofani, Alessia Colosimo, Valentina Guida, Bruno Dallapiccola, Paolo Palma, Emidio Procaccini, Anna C. Berardi, Francesco Velardi, Anna Teti, Salvatore Iannace

Research output: Contribution to journalArticlepeer-review


The design of bioactive scaffold materials able to guide cellular processes involved in new-tissue genesis is key determinant in bone tissue engineering. The aim of this study was the design and characterization of novel multi-phase biomaterials to be processed for the fabrication of 3D porous scaffolds able to provide a temporary biocompatible substrate for mesenchymal stem cells (MSCs) adhesion, proliferation and osteogenic differentiation. The biomaterials were prepared by blending poly(ε-caprolactone) (PCL) with thermoplastic zein (TZ), a thermoplastic material obtained by de novo thermoplasticization of zein. Furthermore, to bioactivate the scaffolds, microparticles of osteoconductive hydroxyapatite (HA) were dispersed within the organic phases. Results demonstrated that materials and formulations strongly affected the micro-structural properties and hydrophilicity of the scaffolds and, therefore, had a pivotal role in guiding cell/scaffold interaction. In particular, if compared to neat PCL, PCL-HA composite and PCL/TZ blend, the three-phase PCL/TZ-HA showed improved MSCs adhesion, proliferation and osteogenic differentiation capability, thus demonstrating potential for bone regeneration.

Original languageEnglish
Pages (from-to)2569-2581
Number of pages13
JournalJournal of Materials Science: Materials in Medicine
Issue number9
Publication statusPublished - Sep 2010

ASJC Scopus subject areas

  • Biophysics
  • Biomaterials
  • Bioengineering
  • Biomedical Engineering


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