Design, synthesis and in vitro antitumour activity of new heteroaryl ethylenes

Cosimo G. Fortuna, Vincenza Barresi, Carmela Bonaccorso, Giuseppe Consiglio, Salvatore Failla, Angela Trovato-Salinaro, Giuseppe Musumarra

Research output: Contribution to journalArticlepeer-review

Abstract

Almond and VolSurf + modelling procedures allowed the structural design of new di- and mono-heteroaryl-ethylenes. The structural modifications suggested by the molecular modelling were verified by the synthesis of the designed molecules and by the evaluation of their in vitro activities against two lung tumour cell lines, A549 and H226. 2-{(E)-2-[5′-(Dibutylamino)-2,2′- bithien-5-yl]vinyl}-1-methylquinolinium iodide exhibited in vitro antiproliferative activity two orders of magnitude higher than that of the most active compound previously synthesized in our laboratory.

Original languageEnglish
Pages (from-to)221-227
Number of pages7
JournalEuropean Journal of Medicinal Chemistry
Volume47
Issue number1
DOIs
Publication statusPublished - Jan 2012

Keywords

  • Antitumour compounds
  • Heterocycles
  • Molecular modelling
  • QSAR

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

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