Abstract
Localization and distribution of desmin and vimentin have been studied in different neuromuscular disorders using monoclonal antibodies. We have demonstrated that vimentin, although virtually absent in normal human muscle fibers, is expressed in regenerating fibers in different neuromuscular disorders. Moreover, these fibers showed a strong positivity with desmin antibodies. In normal muscle fibers desmin is only localized at Z-line level. These results suggest that desmin and vimentin may be over-expressed during muscle regeneration processes, probably because of their importance in the structural organization of the sarcomere.
| Original language | English |
|---|---|
| Pages (from-to) | 88-92 |
| Number of pages | 5 |
| Journal | Acta Neuropathologica |
| Volume | 85 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Dec 1992 |
Keywords
- Desmin
- Immunohistochemistry
- Muscle
- Regeneration
- Vimentin
ASJC Scopus subject areas
- Neuroscience(all)
- Pathology and Forensic Medicine
- Clinical Neurology
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Cite this
Gallanti, A., Prelle, A., Moggio, M., Ciscato, P., Checcarelli, N., Sciacco, M., Comini, A., & Scarlato, G. (1992). Desmin and Vimentin as markers of regeneration in muscle diseases. Acta Neuropathologica, 85(1), 88-92. https://doi.org/10.1007/BF00304637