Desmin and Vimentin as markers of regeneration in muscle diseases

A. Gallanti, A. Prelle, M. Moggio, P. Ciscato, N. Checcarelli, M. Sciacco, A. Comini, G. Scarlato

Research output: Contribution to journalArticle

Abstract

Localization and distribution of desmin and vimentin have been studied in different neuromuscular disorders using monoclonal antibodies. We have demonstrated that vimentin, although virtually absent in normal human muscle fibers, is expressed in regenerating fibers in different neuromuscular disorders. Moreover, these fibers showed a strong positivity with desmin antibodies. In normal muscle fibers desmin is only localized at Z-line level. These results suggest that desmin and vimentin may be over-expressed during muscle regeneration processes, probably because of their importance in the structural organization of the sarcomere.

Original languageEnglish
Pages (from-to)88-92
Number of pages5
JournalActa Neuropathologica
Volume85
Issue number1
DOIs
Publication statusPublished - Dec 1992

Keywords

  • Desmin
  • Immunohistochemistry
  • Muscle
  • Regeneration
  • Vimentin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pathology and Forensic Medicine
  • Clinical Neurology

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  • Cite this

    Gallanti, A., Prelle, A., Moggio, M., Ciscato, P., Checcarelli, N., Sciacco, M., Comini, A., & Scarlato, G. (1992). Desmin and Vimentin as markers of regeneration in muscle diseases. Acta Neuropathologica, 85(1), 88-92. https://doi.org/10.1007/BF00304637