Desmopressin-induced thrombocytopenia in type I platelet discordant von Willebrand disease

G. Castaman, F. Rodeghiero, A. Lattuada, P. M. Mannucci

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Thrombocytopenia after desmopressin (DDAVP) infusion is usually observed in patients with type IIB von Willebrand disease (vWD). No other subtypes of vWD with thrombocytopenia after DDAVP have been reported so far. We describe here the occurrence of thrombocytopenia after DDAVP in a 39 year old male and his son with phenotypic characteristics of type I vWD, 'platelet discordant subtype'. After DDAVP, the abnormal ristocetin cofactor/von Willebrand factor antigen ratio in plasma was not corrected and the bleeding time remained markedly prolonged. Platelet count dropped 30 min after DDAVP (from 279 to 96 x 10 3/μL in the propositus and from 298 to 116 x 10 3/μL in his affected son) and returned to normal at 60 min. Platelet clumping was evident on peripheral blood smears obtained after infusion. These cases indicate that after DDAVP thrombocytopenia can occur in vWD other than type IIB.

Original languageEnglish
Pages (from-to)5-9
Number of pages5
JournalAmerican Journal of Hematology
Volume43
Issue number1
Publication statusPublished - 1993

Fingerprint

Deamino Arginine Vasopressin
Thrombocytopenia
Type 2 von Willebrand Disease
von Willebrand Factor
Nuclear Family
Blood Platelets
Type 1 von Willebrand Disease
von Willebrand Diseases
Bleeding Time
Platelet type Von Willebrand disease
Platelet Count

Keywords

  • DDAVP
  • post-DDAVP thrombocytopenia
  • ristocetin cofactor

ASJC Scopus subject areas

  • Hematology

Cite this

Desmopressin-induced thrombocytopenia in type I platelet discordant von Willebrand disease. / Castaman, G.; Rodeghiero, F.; Lattuada, A.; Mannucci, P. M.

In: American Journal of Hematology, Vol. 43, No. 1, 1993, p. 5-9.

Research output: Contribution to journalArticle

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