Abstract
Desmosomes guarantee the integrity of the epidermis, by functioning both as an adhesive complex and as cell-surface attachment site for the keratin intermediate filaments of the cytoskeleton. Considerable progress has been made in our knowledge of desmosomes and their components. The structure and function of many of the desmosomal molecules have been determined, and a number of the molecular interactions between desmosomal proteins have been elucidated. Desmosomal proteins are major antigens in pemphigus. Each type of pemphigus has its own antigenic targets, but in the last few years it has been shown that certain autoantibody populations are not restricted to just one form of pemphigus. The production of autoantibodies against multiple intracellular and extracellular desmosomal proteins, whose pathogenic role remains to be elucidated, suggests an overlapping distribution of antibody specificities among different forms of pemphigus.
| Original language | English |
|---|---|
| Pages (from-to) | 255-261 |
| Number of pages | 7 |
| Journal | European Journal of Dermatology |
| Volume | 10 |
| Issue number | 4 |
| Publication status | Published - 2000 |
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Keywords
- Autoimmunity
- Cadherins
- Cell adhesion
- Desmosome
- Epitope spreading
- Pemphigus
ASJC Scopus subject areas
- Dermatology
Cite this
Desmosomes and their autoimmune pathologies. / Cozzani, Emanuele; Cacciapuoti, Marco; Parodi, Aurora; Ghohestani, Reza; Rebora, Alfredo.
In: European Journal of Dermatology, Vol. 10, No. 4, 2000, p. 255-261.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Desmosomes and their autoimmune pathologies
AU - Cozzani, Emanuele
AU - Cacciapuoti, Marco
AU - Parodi, Aurora
AU - Ghohestani, Reza
AU - Rebora, Alfredo
PY - 2000
Y1 - 2000
N2 - Desmosomes guarantee the integrity of the epidermis, by functioning both as an adhesive complex and as cell-surface attachment site for the keratin intermediate filaments of the cytoskeleton. Considerable progress has been made in our knowledge of desmosomes and their components. The structure and function of many of the desmosomal molecules have been determined, and a number of the molecular interactions between desmosomal proteins have been elucidated. Desmosomal proteins are major antigens in pemphigus. Each type of pemphigus has its own antigenic targets, but in the last few years it has been shown that certain autoantibody populations are not restricted to just one form of pemphigus. The production of autoantibodies against multiple intracellular and extracellular desmosomal proteins, whose pathogenic role remains to be elucidated, suggests an overlapping distribution of antibody specificities among different forms of pemphigus.
AB - Desmosomes guarantee the integrity of the epidermis, by functioning both as an adhesive complex and as cell-surface attachment site for the keratin intermediate filaments of the cytoskeleton. Considerable progress has been made in our knowledge of desmosomes and their components. The structure and function of many of the desmosomal molecules have been determined, and a number of the molecular interactions between desmosomal proteins have been elucidated. Desmosomal proteins are major antigens in pemphigus. Each type of pemphigus has its own antigenic targets, but in the last few years it has been shown that certain autoantibody populations are not restricted to just one form of pemphigus. The production of autoantibodies against multiple intracellular and extracellular desmosomal proteins, whose pathogenic role remains to be elucidated, suggests an overlapping distribution of antibody specificities among different forms of pemphigus.
KW - Autoimmunity
KW - Cadherins
KW - Cell adhesion
KW - Desmosome
KW - Epitope spreading
KW - Pemphigus
UR - http://www.scopus.com/inward/record.url?scp=0034032982&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034032982&partnerID=8YFLogxK
M3 - Article
VL - 10
SP - 255
EP - 261
JO - European Journal of Dermatology
JF - European Journal of Dermatology
SN - 1167-1122
IS - 4
ER -