Detailed volumetric analysis of the hypothalamus in behavioral variant frontotemporal dementia

Martina Bocchetta, Elizabeth Gordon, Emily Manning, Josephine Barnes, David M. Cash, Miklos Espak, David L. Thomas, Marc Modat, Martin N. Rossor, Jason D. Warren, Sebastien Ourselin, Giovanni B. Frisoni, Jonathan D. Rohrer

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Abnormal eating behaviors are frequently reported in behavioral variant frontotemporal dementia (bvFTD). The hypothalamus is the regulatory center for feeding and satiety but its involvement in bvFTD has not been fully clarified, partly due to its difficult identification on MR images. We measured hypothalamic volume in 18 patients with bvFTD (including 9 MAPT and 6 C9orf72 mutation carriers) and 18 cognitively normal controls using a novel optimized multimodal segmentation protocol, combining 3D T1 and T2-weighted 3T MRIs (intrarater intraclass correlation coefficients ≥0.93). The whole hypothalamus was subsequently segmented into five subunits: the anterior (superior and inferior), tuberal (superior and inferior), and posterior regions. The presence of abnormal eating behavior was assessed with the revised version of the Cambridge Behavioural Inventory (CBI-R). The bvFTD group showed a 17 % lower hypothalamic volume compared with controls (p 3 (corrected for total intracranial volume). In the hypothalamic subunit analysis, the superior parts of the anterior and tuberal regions and the posterior region were significantly smaller in the bvFTD group compared with controls. There was a trend for a smaller hypothalamic volume, particularly in the superior tuberal region, in those with severe eating disturbance scores on the CBI-R. Differences were seen between the two genetic subgroups with significantly smaller volumes in the MAPT but not the C9orf72 group compared with controls. In summary, bvFTD patients had lower hypothalamic volumes compared with controls. Different genetic mutations may have a differential impact on the hypothalamus.

Original languageEnglish
Pages (from-to)2635-2642
Number of pages8
JournalJournal of Neurology
Volume262
Issue number12
DOIs
Publication statusPublished - Dec 1 2015

Fingerprint

Frontotemporal Dementia
Hypothalamus
Feeding Behavior
Mutation
Eating
Equipment and Supplies

Keywords

  • Eating disorders
  • Frontotemporal dementia
  • Hypothalamus
  • Volumetric MRI

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Bocchetta, M., Gordon, E., Manning, E., Barnes, J., Cash, D. M., Espak, M., ... Rohrer, J. D. (2015). Detailed volumetric analysis of the hypothalamus in behavioral variant frontotemporal dementia. Journal of Neurology, 262(12), 2635-2642. https://doi.org/10.1007/s00415-015-7885-2

Detailed volumetric analysis of the hypothalamus in behavioral variant frontotemporal dementia. / Bocchetta, Martina; Gordon, Elizabeth; Manning, Emily; Barnes, Josephine; Cash, David M.; Espak, Miklos; Thomas, David L.; Modat, Marc; Rossor, Martin N.; Warren, Jason D.; Ourselin, Sebastien; Frisoni, Giovanni B.; Rohrer, Jonathan D.

In: Journal of Neurology, Vol. 262, No. 12, 01.12.2015, p. 2635-2642.

Research output: Contribution to journalArticle

Bocchetta, M, Gordon, E, Manning, E, Barnes, J, Cash, DM, Espak, M, Thomas, DL, Modat, M, Rossor, MN, Warren, JD, Ourselin, S, Frisoni, GB & Rohrer, JD 2015, 'Detailed volumetric analysis of the hypothalamus in behavioral variant frontotemporal dementia', Journal of Neurology, vol. 262, no. 12, pp. 2635-2642. https://doi.org/10.1007/s00415-015-7885-2
Bocchetta, Martina ; Gordon, Elizabeth ; Manning, Emily ; Barnes, Josephine ; Cash, David M. ; Espak, Miklos ; Thomas, David L. ; Modat, Marc ; Rossor, Martin N. ; Warren, Jason D. ; Ourselin, Sebastien ; Frisoni, Giovanni B. ; Rohrer, Jonathan D. / Detailed volumetric analysis of the hypothalamus in behavioral variant frontotemporal dementia. In: Journal of Neurology. 2015 ; Vol. 262, No. 12. pp. 2635-2642.
@article{aab6866fb717422fb7312ac148a09a07,
title = "Detailed volumetric analysis of the hypothalamus in behavioral variant frontotemporal dementia",
abstract = "Abnormal eating behaviors are frequently reported in behavioral variant frontotemporal dementia (bvFTD). The hypothalamus is the regulatory center for feeding and satiety but its involvement in bvFTD has not been fully clarified, partly due to its difficult identification on MR images. We measured hypothalamic volume in 18 patients with bvFTD (including 9 MAPT and 6 C9orf72 mutation carriers) and 18 cognitively normal controls using a novel optimized multimodal segmentation protocol, combining 3D T1 and T2-weighted 3T MRIs (intrarater intraclass correlation coefficients ≥0.93). The whole hypothalamus was subsequently segmented into five subunits: the anterior (superior and inferior), tuberal (superior and inferior), and posterior regions. The presence of abnormal eating behavior was assessed with the revised version of the Cambridge Behavioural Inventory (CBI-R). The bvFTD group showed a 17 {\%} lower hypothalamic volume compared with controls (p 3 (corrected for total intracranial volume). In the hypothalamic subunit analysis, the superior parts of the anterior and tuberal regions and the posterior region were significantly smaller in the bvFTD group compared with controls. There was a trend for a smaller hypothalamic volume, particularly in the superior tuberal region, in those with severe eating disturbance scores on the CBI-R. Differences were seen between the two genetic subgroups with significantly smaller volumes in the MAPT but not the C9orf72 group compared with controls. In summary, bvFTD patients had lower hypothalamic volumes compared with controls. Different genetic mutations may have a differential impact on the hypothalamus.",
keywords = "Eating disorders, Frontotemporal dementia, Hypothalamus, Volumetric MRI",
author = "Martina Bocchetta and Elizabeth Gordon and Emily Manning and Josephine Barnes and Cash, {David M.} and Miklos Espak and Thomas, {David L.} and Marc Modat and Rossor, {Martin N.} and Warren, {Jason D.} and Sebastien Ourselin and Frisoni, {Giovanni B.} and Rohrer, {Jonathan D.}",
year = "2015",
month = "12",
day = "1",
doi = "10.1007/s00415-015-7885-2",
language = "English",
volume = "262",
pages = "2635--2642",
journal = "Journal of Neurology",
issn = "0340-5354",
publisher = "Dr. Dietrich Steinkopff Verlag GmbH and Co. KG",
number = "12",

}

TY - JOUR

T1 - Detailed volumetric analysis of the hypothalamus in behavioral variant frontotemporal dementia

AU - Bocchetta, Martina

AU - Gordon, Elizabeth

AU - Manning, Emily

AU - Barnes, Josephine

AU - Cash, David M.

AU - Espak, Miklos

AU - Thomas, David L.

AU - Modat, Marc

AU - Rossor, Martin N.

AU - Warren, Jason D.

AU - Ourselin, Sebastien

AU - Frisoni, Giovanni B.

AU - Rohrer, Jonathan D.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Abnormal eating behaviors are frequently reported in behavioral variant frontotemporal dementia (bvFTD). The hypothalamus is the regulatory center for feeding and satiety but its involvement in bvFTD has not been fully clarified, partly due to its difficult identification on MR images. We measured hypothalamic volume in 18 patients with bvFTD (including 9 MAPT and 6 C9orf72 mutation carriers) and 18 cognitively normal controls using a novel optimized multimodal segmentation protocol, combining 3D T1 and T2-weighted 3T MRIs (intrarater intraclass correlation coefficients ≥0.93). The whole hypothalamus was subsequently segmented into five subunits: the anterior (superior and inferior), tuberal (superior and inferior), and posterior regions. The presence of abnormal eating behavior was assessed with the revised version of the Cambridge Behavioural Inventory (CBI-R). The bvFTD group showed a 17 % lower hypothalamic volume compared with controls (p 3 (corrected for total intracranial volume). In the hypothalamic subunit analysis, the superior parts of the anterior and tuberal regions and the posterior region were significantly smaller in the bvFTD group compared with controls. There was a trend for a smaller hypothalamic volume, particularly in the superior tuberal region, in those with severe eating disturbance scores on the CBI-R. Differences were seen between the two genetic subgroups with significantly smaller volumes in the MAPT but not the C9orf72 group compared with controls. In summary, bvFTD patients had lower hypothalamic volumes compared with controls. Different genetic mutations may have a differential impact on the hypothalamus.

AB - Abnormal eating behaviors are frequently reported in behavioral variant frontotemporal dementia (bvFTD). The hypothalamus is the regulatory center for feeding and satiety but its involvement in bvFTD has not been fully clarified, partly due to its difficult identification on MR images. We measured hypothalamic volume in 18 patients with bvFTD (including 9 MAPT and 6 C9orf72 mutation carriers) and 18 cognitively normal controls using a novel optimized multimodal segmentation protocol, combining 3D T1 and T2-weighted 3T MRIs (intrarater intraclass correlation coefficients ≥0.93). The whole hypothalamus was subsequently segmented into five subunits: the anterior (superior and inferior), tuberal (superior and inferior), and posterior regions. The presence of abnormal eating behavior was assessed with the revised version of the Cambridge Behavioural Inventory (CBI-R). The bvFTD group showed a 17 % lower hypothalamic volume compared with controls (p 3 (corrected for total intracranial volume). In the hypothalamic subunit analysis, the superior parts of the anterior and tuberal regions and the posterior region were significantly smaller in the bvFTD group compared with controls. There was a trend for a smaller hypothalamic volume, particularly in the superior tuberal region, in those with severe eating disturbance scores on the CBI-R. Differences were seen between the two genetic subgroups with significantly smaller volumes in the MAPT but not the C9orf72 group compared with controls. In summary, bvFTD patients had lower hypothalamic volumes compared with controls. Different genetic mutations may have a differential impact on the hypothalamus.

KW - Eating disorders

KW - Frontotemporal dementia

KW - Hypothalamus

KW - Volumetric MRI

UR - http://www.scopus.com/inward/record.url?scp=84947863315&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84947863315&partnerID=8YFLogxK

U2 - 10.1007/s00415-015-7885-2

DO - 10.1007/s00415-015-7885-2

M3 - Article

AN - SCOPUS:84947863315

VL - 262

SP - 2635

EP - 2642

JO - Journal of Neurology

JF - Journal of Neurology

SN - 0340-5354

IS - 12

ER -