Detecting illicit drugs and metabolites in wastewater using high performance liquid chromatography-tandem mass spectrometry

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Abstract

High-performance liquid chromatography-tandem mass spectrometry (HPLC-MS) was used to detect illicit drugs and metabolites in wastewater. Cocaine, amphetamines, morphine and derivatives, the main metabolite of tetahydrocannabinol (THC-COOH) methadone and some of their metabolites in wastewater was developed by using solid phase extraction (SPE) and HPLC-MS. Two main factors, matrix effect and sensitivity were carefully considered to optimize the analytical conditions in wastewater. Samples were collected from the influent and effluent wastewater of a treatment plant. Drugs were analyzed using an XTerra MS C18, 100×2.1 mm, 3.5«mu»m columns at a flow rate of 200«mu»L min-1. The mass spectrometer system was an API 3000 triple quadrupole mass spectrometer, equipped with a turbo ion spray source. The presence of these substances in WWTPs was verified, and each compound was quantified in both the influents and effluents.

Original languageEnglish
Pages (from-to)7-9
Number of pages3
JournalSpectroscopy Europe
Volume19
Issue number4
Publication statusPublished - Aug 2007

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metabolites
liquid chromatography
High performance liquid chromatography
Street Drugs
Metabolites
Mass spectrometry
Wastewater
drugs
mass spectroscopy
effluents
mass spectrometers
amphetamines
morphine
Mass spectrometers
thermohaline circulation
Effluents
application programming interface
Morphine Derivatives
Amphetamines
Dronabinol

ASJC Scopus subject areas

  • Instrumentation

Cite this

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abstract = "High-performance liquid chromatography-tandem mass spectrometry (HPLC-MS) was used to detect illicit drugs and metabolites in wastewater. Cocaine, amphetamines, morphine and derivatives, the main metabolite of tetahydrocannabinol (THC-COOH) methadone and some of their metabolites in wastewater was developed by using solid phase extraction (SPE) and HPLC-MS. Two main factors, matrix effect and sensitivity were carefully considered to optimize the analytical conditions in wastewater. Samples were collected from the influent and effluent wastewater of a treatment plant. Drugs were analyzed using an XTerra MS C18, 100×2.1 mm, 3.5«mu»m columns at a flow rate of 200«mu»L min-1. The mass spectrometer system was an API 3000 triple quadrupole mass spectrometer, equipped with a turbo ion spray source. The presence of these substances in WWTPs was verified, and each compound was quantified in both the influents and effluents.",
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AU - Zuccato, Ettore

AU - Chiabrando, Chiara

AU - Fanelli, Roberto

AU - Bagnati, Renzo

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