Detecting illicit drugs and metabolites in wastewater using high performance liquid chromatography-tandem mass spectrometry

Sara Castiglioni, Ettore Zuccato, Chiara Chiabrando, Roberto Fanelli, Renzo Bagnati

Research output: Contribution to journalArticlepeer-review

Abstract

High-performance liquid chromatography-tandem mass spectrometry (HPLC-MS) was used to detect illicit drugs and metabolites in wastewater. Cocaine, amphetamines, morphine and derivatives, the main metabolite of tetahydrocannabinol (THC-COOH) methadone and some of their metabolites in wastewater was developed by using solid phase extraction (SPE) and HPLC-MS. Two main factors, matrix effect and sensitivity were carefully considered to optimize the analytical conditions in wastewater. Samples were collected from the influent and effluent wastewater of a treatment plant. Drugs were analyzed using an XTerra MS C18, 100×2.1 mm, 3.5«mu»m columns at a flow rate of 200«mu»L min-1. The mass spectrometer system was an API 3000 triple quadrupole mass spectrometer, equipped with a turbo ion spray source. The presence of these substances in WWTPs was verified, and each compound was quantified in both the influents and effluents.

Original languageEnglish
Pages (from-to)7-9
Number of pages3
JournalSpectroscopy Europe
Volume19
Issue number4
Publication statusPublished - Aug 2007

ASJC Scopus subject areas

  • Instrumentation

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