Abstract
In the last 15 years, the estimated prevalence of autoimmune diseases increased from about 4 to 9.4 %. Autoimmune co-morbidity (i.e., the association between two or more autoimmune diseases in the same patient) is present in 0.4-0.5 % of the worldwide population, more frequently in patients with multiple sclerosis, rheumatoid arthritis, autoimmune thyroid disease, type 1 diabetes, inflammatory bowel disease and vitiligo. The most common associations between autoimmune diseases define two clusters: the multiple autoimmune syndromes and overlap syndromes. This review highlights the importance of multiple antibody assays in the diagnosis of multiple autoimmune and overlap syndromes and summarizes the general conditions of autoantibody detection using the model of the five W's: why, who, what, when and where. These conditions represent a new challenge for clinical and laboratory autoimmunologists, who, in a multidisciplinary arena, cooperate in investigating and treating multiple autoimmune disorders.
| Original language | English |
|---|---|
| Pages (from-to) | 425-431 |
| Number of pages | 7 |
| Journal | Immunologic Research |
| Volume | 56 |
| Issue number | 2-3 |
| DOIs | |
| Publication status | Published - Jul 2013 |
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Keywords
- Autoimmune liver diseases
- Autoimmunology
- Co-morbidity
- Connective tissue diseases
- Multiple autoimmune syndromes
- Overlap syndromes
- Polyautoimmunity
ASJC Scopus subject areas
- Immunology
Cite this
Detecting multiple autoantibodies to diagnose autoimmune co-morbidity (multiple autoimmune syndromes and overlap syndromes) : A challenge for the autoimmunologist. / Tozzoli, Renato; Sorrentino, Maria Concetta; Bizzaro, Nicola.
In: Immunologic Research, Vol. 56, No. 2-3, 07.2013, p. 425-431.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Detecting multiple autoantibodies to diagnose autoimmune co-morbidity (multiple autoimmune syndromes and overlap syndromes)
T2 - A challenge for the autoimmunologist
AU - Tozzoli, Renato
AU - Sorrentino, Maria Concetta
AU - Bizzaro, Nicola
PY - 2013/7
Y1 - 2013/7
N2 - In the last 15 years, the estimated prevalence of autoimmune diseases increased from about 4 to 9.4 %. Autoimmune co-morbidity (i.e., the association between two or more autoimmune diseases in the same patient) is present in 0.4-0.5 % of the worldwide population, more frequently in patients with multiple sclerosis, rheumatoid arthritis, autoimmune thyroid disease, type 1 diabetes, inflammatory bowel disease and vitiligo. The most common associations between autoimmune diseases define two clusters: the multiple autoimmune syndromes and overlap syndromes. This review highlights the importance of multiple antibody assays in the diagnosis of multiple autoimmune and overlap syndromes and summarizes the general conditions of autoantibody detection using the model of the five W's: why, who, what, when and where. These conditions represent a new challenge for clinical and laboratory autoimmunologists, who, in a multidisciplinary arena, cooperate in investigating and treating multiple autoimmune disorders.
AB - In the last 15 years, the estimated prevalence of autoimmune diseases increased from about 4 to 9.4 %. Autoimmune co-morbidity (i.e., the association between two or more autoimmune diseases in the same patient) is present in 0.4-0.5 % of the worldwide population, more frequently in patients with multiple sclerosis, rheumatoid arthritis, autoimmune thyroid disease, type 1 diabetes, inflammatory bowel disease and vitiligo. The most common associations between autoimmune diseases define two clusters: the multiple autoimmune syndromes and overlap syndromes. This review highlights the importance of multiple antibody assays in the diagnosis of multiple autoimmune and overlap syndromes and summarizes the general conditions of autoantibody detection using the model of the five W's: why, who, what, when and where. These conditions represent a new challenge for clinical and laboratory autoimmunologists, who, in a multidisciplinary arena, cooperate in investigating and treating multiple autoimmune disorders.
KW - Autoimmune liver diseases
KW - Autoimmunology
KW - Co-morbidity
KW - Connective tissue diseases
KW - Multiple autoimmune syndromes
KW - Overlap syndromes
KW - Polyautoimmunity
UR - http://www.scopus.com/inward/record.url?scp=84879556321&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84879556321&partnerID=8YFLogxK
U2 - 10.1007/s12026-013-8418-7
DO - 10.1007/s12026-013-8418-7
M3 - Article
C2 - 23606120
AN - SCOPUS:84879556321
VL - 56
SP - 425
EP - 431
JO - Immunologic Research
JF - Immunologic Research
SN - 0257-277X
IS - 2-3
ER -